HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 192
+	Hs
		655307 P85A_HUMAN (1-724): 0: 596: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Mm
		643072 P85A_MOUSE (1-724): 0: 592: 95.99		RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71
+	Hs
		545215 P85A_HUMAN (1-724): 0: 596: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		655467 P85A_HUMAN (1-724): 0: 596: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		655316 P85A_HUMAN (1-724): 0: 596: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		655295 P85A_HUMAN (1-724): 0: 596: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		655297 P85A_HUMAN (1-724): 0: 596: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436167 P85A_HUMAN (1-724): 0: 596: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564419 P85A_HUMAN (1-724): 0: 596: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		129270 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		129190 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		129334 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		129259 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		129275 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		129260 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		129262 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		129193 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		900751 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		564631 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Dm
		776916 CDGAP_DROME (11-619): 1.7e-63: 232: 15.61		RAC1_DROME (1-192): 2.16e-81: 241: 89.06