HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: ACTS (P68133)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23353701
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~RhoGAP
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 377
+	Hs
		129258 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		64678 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		64690 RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		891826 RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		891894 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		929924 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		892060 RHG35_HUMAN (89-325): 8.1e-55: 206: 23.46		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		932401 RHG35_HUMAN (89-325): 8.1e-55: 206: 23.46		ACTC_HUMAN (1-377): 0: 604: 98.94
+	Hs
		253332 SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		891832 RHG17_HUMAN (41-350): 6.97e-54: 201: 18.50		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		891856 RHG27_HUMAN (34-304): 2.54e-53: 200: 18.51		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		929907 RHG27_HUMAN (34-304): 2.54e-53: 200: 18.51		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		112131 M0R0P8_HUMAN (128-294): 1.42e-45: 178: 27.98		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		891744 MYO9B_HUMAN (128-294): 1.43e-45: 178: 27.98		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		929850 MYO9B_HUMAN (128-294): 1.43e-45: 178: 27.98		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Dm
		113868 M9PAY7_DROME (322-428): 1.98e-13: 71.4: 27.78		ACT2_DROME (1-377): 0: 602: 93.37