HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	27708159, 35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 768
+	Hs
		129293 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042017 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1035102 MYO9B_HUMAN (128-294): 1.43e-45: 178: 27.98		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1043452 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1041089 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041194 RGAP1_HUMAN (14-393): 1.43e-54: 200: 15.46		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041395 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1231293 RHG24_HUMAN (94-443): 7.45e-57: 208: 16.76		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Dm
		113895 M9PAY7_DROME (322-428): 1.98e-13: 71.4: 27.78		CUL1_DROME (29-768): 0: 669: 27.49
+	Dm
		186280 O18683_DROME (319-465): 9.73e-10: 63.5: 20.95		CUL1_DROME (29-768): 0: 669: 27.49