HitPredict

Interactor 1: PSB5 (P28074)
Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)
Gene: PSMB5

Interactor 2: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Gene: PSME4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 263 Hs			1 1843
+	Hs
		656062 PSB8_HUMAN (1-261): 7.16e-89: 266: 57.46		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656228 PSA5_HUMAN (28-258): 1.29e-86: 259: 15.64		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		1061392 PSB7_HUMAN (39-251): 2.76e-83: 252: 25.82		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		637689 PSA2_HUMAN (30-259): 6.04e-80: 242: 18.64		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		638132 PSA4_HUMAN (32-255): 1.03e-79: 242: 18.22		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656600 PSB6_HUMAN (43-245): 4.34e-77: 235: 31.37		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Hs
		656115 PSB9_HUMAN (55-242): 2.58e-18: 82.8: 30.16		PSME4_HUMAN (1-1843): 0: 2463: 100.00
+	Sc
		689188 PSA5_YEAST (28-260): 1.87e-80: 244: 17.89		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		675424 PSB5_YEAST (17-257): 9.95e-79: 240: 59.26		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		625943 PSB2_YEAST (53-238): 1.34e-78: 239: 29.03		BLM10_YEAST (74-831): 0: 722: 16.61
+	Sc
		751170 PSB1_YEAST (55-254): 1.48e-70: 217: 26.60		BLM10_YEAST (74-831): 0: 722: 16.61