HitPredict

Interactor 1: 5HT2C (P28335)
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
Gene: HTR2C

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12006486
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0045202 - synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 724
+	Hs
		656994 5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		600726 DRD1_HUMAN (70-385): 2.99e-83: 265: 27.88		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Rn
		495779 ADRB2_RAT (19-438): 1.92e-78: 251: 24.18		DLG4_RAT (1-724): 0: 668: 99.86
+	Hs
		441650 ADRB1_HUMAN (13-409): 5.38e-77: 249: 25.62		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		676818 SSR2_MOUSE (33-413): 7.81e-69: 225: 18.86		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		830267 SSR4_MOUSE (23-389): 1.21e-68: 225: 20.57		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		676812 SSR1_MOUSE (39-387): 1.05e-65: 217: 23.10		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Rn
		677498 SSR4_RAT (19-389): 5.36e-65: 215: 18.70		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		897201 DRD2_MOUSE (306-385): 8.26e-15: 78.2: 47.50		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		658236 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		658227 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		626687 ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		656997 5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		626682 ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		159159 ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Mm
		830268 SSR4_MOUSE (23-389): 1.21e-68: 225: 20.57		DLG2_MOUSE (225-474): 1.48e-18: 92.5: 21.09
+	Hs
		676802 SSR1_HUMAN (39-387): 2.15e-64: 214: 23.10		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Mm
		676813 SSR1_MOUSE (39-387): 1.05e-65: 217: 23.10		DLG2_MOUSE (225-474): 1.48e-18: 92.5: 21.09