HitPredict

Interactor 1: 5HT2C (P28335)
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
Gene: HTR2C

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 458 Hs			1 1630
+	Hs
		626687 ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		658286 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Hs
		658221 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Rn
		574798 ADRB1_RAT (70-438): 1.1e-70: 233: 26.93		MAGI3_RAT (491-1629): 6.69e-63: 239: 14.20
+	Rn
		223210 5HT2C_RAT (1-458): 1.11e-107: 328: 88.04		MPDZ_RAT (963-1201): 3.1e-30: 133: 24.25
+	Hs
		656994 5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Hs
		600726 DRD1_HUMAN (70-385): 2.99e-83: 265: 27.88		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Hs
		280022 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Rn
		495779 ADRB2_RAT (19-438): 1.92e-78: 251: 24.18		DLG4_RAT (812-1187): 3.08e-49: 190: 22.42
+	Hs
		441650 ADRB1_HUMAN (13-409): 5.38e-77: 249: 25.62		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Mm
		676818 SSR2_MOUSE (33-413): 7.81e-69: 225: 18.86		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		830267 SSR4_MOUSE (23-389): 1.21e-68: 225: 20.57		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		676812 SSR1_MOUSE (39-387): 1.05e-65: 217: 23.10		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		280021 5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		658227 5HT2C_HUMAN (1-458): 1.97e-103: 317: 100.00		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		280029 5HT2B_HUMAN (27-401): 1.83e-70: 233: 44.96		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		280028 DRD3_HUMAN (22-385): 4.42e-69: 226: 25.79		MPDZ_HUMAN (953-1212): 1.61e-30: 134: 21.40
+	Hs
		656997 5HT2A_HUMAN (4-458): 5.97e-84: 267: 50.22		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		626682 ADA1D_HUMAN (24-447): 1.69e-77: 253: 24.47		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Mm
		830268 SSR4_MOUSE (23-389): 1.21e-68: 225: 20.57		DLG2_MOUSE (587-879): 2.8e-21: 103: 18.52