HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007049 - cell cycle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 168
+	Hs
		658871 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		CDN2D_HUMAN (6-159): 4e-48: 155: 45.81
+	Rn
		926518 MK01_RAT (10-360): 4.96e-158: 449: 99.72		CSKI1_RAT (1-159): 7.2e-30: 116: 14.69
+	Hs
		658865 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93
+	Hs
		647524 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93
+	Hs
		658830 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Hs
		658831 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22
+	Hs
		647496 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Rn
		926505 MK01_RAT (10-360): 4.96e-158: 449: 99.72		TANC1_RAT (82-168): 3.37e-12: 65.4: 22.47
+	Hs
		790791 MK14_HUMAN (18-356): 7.86e-112: 332: 48.97		CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57
+	Mm
		814053 MK14_MOUSE (18-356): 3.49e-111: 330: 48.97		MIB1_MOUSE (74-168): 3.38e-14: 71.1: 21.88