Protein: PTPRA
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

Gene: PTPRA
Organism: Homo sapiens
Interactions: 139
UniProt ID: P18433

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

614675

GRB2
Growth factor receptor-bound protein 2

16

20

Small-scale

0.988

High

614649

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

7

17

High-throughput

0.958

High

557073

SRC
Proto-oncogene tyrosine-protein kinase Src

4

20

Small-scale

0.903

High

362742

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.865

High

614646

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

3

17

Small-scale

0.858

High

410603

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.754

High

614659

MERL
Merlin

2

7

High-throughput

0.754

High

463898

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.724

High

614657

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

127273

LEG8
Galectin-8

3

20

High-throughput

0.667

High

141985

FCN1
Ficolin-1

3

4

High-throughput

0.667

High

480694

LEG1
Galectin-1

3

20

High-throughput

0.662

High

139374

NCHL1
Neural cell adhesion molecule L1-like protein

1

7

Small-scale

0.618

High

222016

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.618

High

440351

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

614650

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

17

Small-scale

0.618

High

614654

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.618

High

614656

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.618

High

614664

CRK
Adapter molecule crk

1

17

High-throughput

0.618

High

614679

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

614684

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

18

High-throughput

0.618

High

614690

SHB
SH2 domain-containing adapter protein B

1

20

High-throughput

0.618

High

614733

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.618

High

614666

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.602

High

614655

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.590

High

614671

XPO2
Exportin-2

2

14

High-throughput

0.584

High

614686

GAB1
GRB2-associated-binding protein 1

2

8

High-throughput

0.584

High

614693

GRDN
Girdin

2

3

High-throughput

0.584

High

614699

GRIN3
G protein-regulated inducer of neurite outgrowth 3

2

2

High-throughput

0.584

High

614700

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

2

1

High-throughput

0.584

High

614745

BAIP2
BAR/IMD domain-containing adapter protein 2

2

2

High-throughput

0.584

High

614680

SP4
Transcription factor Sp4

2

2

High-throughput

0.574

High

614704

MYCPP
C-myc promoter-binding protein

2

1

High-throughput

0.574

High

614706

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

2

1

High-throughput

0.574

High

614711

TPC2
Two pore channel protein 2

2

10

High-throughput

0.574

High

614737

ASND1
Asparagine synthetase domain-containing protein 1

2

1

High-throughput

0.574

High

614662

GDNF
Glial cell line-derived neurotrophic factor

2

1

High-throughput

0.571

High

595029

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

Small-scale

0.561

High

614677

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

4

Small-scale

0.561

High

614678

BASP1
Brain acid soluble protein 1

2

0

High-throughput

0.559

High

614698

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.553

High

415337

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

614660

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

4

High-throughput

0.541

High

614673

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

5

High-throughput

0.541

High

609568

LEG3
Galectin-3

1

20

High-throughput

0.536

High

614676

1433Z
14-3-3 protein zeta/delta

1

14

High-throughput

0.536

High

614683

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

4

High-throughput

0.536

High

614710

RN149
E3 ubiquitin-protein ligase RNF149

1

10

High-throughput

0.536

High

614712

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

7

High-throughput

0.536

High

614748

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

614648

LMNB1
Lamin-B1

1

3

High-throughput

0.515

High

614727

ATX2
Ataxin-2

1

0

High-throughput

0.513

High

614728

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

High-throughput

0.513

High

614729

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

0

High-throughput

0.513

High

614743

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

614747

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.513

High

553115

KCRB
Creatine kinase B-type

1

0

High-throughput

0.493

High

125215

LEG9
Galectin-9

1

20

High-throughput

0.489

High

134435

EF2K
Eukaryotic elongation factor 2 kinase

1

2

High-throughput

0.489

High

614661

ARL2
ADP-ribosylation factor-like protein 2

1

5

High-throughput

0.489

High

614692

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

614719

LEG12
Galectin-12

1

20

High-throughput

0.489

High

614739

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

7

High-throughput

0.489

High

388041

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

614669

GAS1
Growth arrest-specific protein 1

1

0

Small-scale

0.480

High

133940

IPO5
Importin-5

1

5

High-throughput

0.479

High

212374

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.479

High

239715

PCDH7
Protocadherin-7

1

20

High-throughput

0.479

High

254048

CTND1
Catenin delta-1

1

20

High-throughput

0.479

High

328776

UNC5C
Netrin receptor UNC5C

1

7

High-throughput

0.479

High

374387

RASH
GTPase HRas

1

11

High-throughput

0.479

High

614647

CADH2
Cadherin-2

1

20

High-throughput

0.479

High

614652

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.479

High

614653

CALX
Calnexin

1

8

High-throughput

0.479

High

614658

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

614663

MUC18
Cell surface glycoprotein MUC18

1

15

High-throughput

0.479

High

614665

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.479

High

614667

NUMB
Protein numb homolog

1

4

High-throughput

0.479

High

614672

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

614681

NOTC2
Neurogenic locus notch homolog protein 2

1

3

High-throughput

0.479

High

614685

ANK3
Ankyrin-3

1

1

High-throughput

0.479

High

614688

PDIA6
Protein disulfide-isomerase A6

1

13

High-throughput

0.479

High

614701

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.479

High

614702

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

2

High-throughput

0.479

High

614703

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

6

High-throughput

0.479

High

614705

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.479

High

614708

UNC5B
Netrin receptor UNC5B

1

5

High-throughput

0.479

High

614709

TXND5
Thioredoxin domain-containing protein 5

1

13

High-throughput

0.479

High

614714

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

5

High-throughput

0.479

High

614715

GCN1
Stalled ribosome sensor GCN1

1

10

High-throughput

0.479

High

614716

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

2

High-throughput

0.479

High

614717

TNPO1
Transportin-1

1

10

High-throughput

0.479

High

614721

CERS2
Ceramide synthase 2

1

4

High-throughput

0.479

High

614726

NIBA2
Protein Niban 2

1

1

High-throughput

0.479

High

614730

PAR6B
Partitioning defective 6 homolog beta

1

2

High-throughput

0.479

High

614732

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

6

High-throughput

0.479

High

614734

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

5

High-throughput

0.479

High

614741

ATX10
Ataxin-10

1

1

High-throughput

0.479

High

614744

AMFR
E3 ubiquitin-protein ligase AMFR

1

13

High-throughput

0.479

High

614691

SMN
Survival motor neuron protein

1

1

High-throughput

0.470

High

219272

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.458

High

279276

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

360372

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.458

High

568754

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

0

High-throughput

0.458

High

614651

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.458

High

614689

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.458

High

614713

FRS2
Fibroblast growth factor receptor substrate 2

1

0

High-throughput

0.458

High

614718

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

614724

XPO6
Exportin-6

1

0

High-throughput

0.458

High

614725

ERBIN
Erbin

1

0

High-throughput

0.458

High

614736

TMM51
Transmembrane protein 51

1

0

High-throughput

0.458

High

614742

NCDN
Neurochondrin

1

0

High-throughput

0.458

High

254792

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

614687

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

614695

Q5VWH6
Protein tyrosine phosphatase receptor type E

1

14

High-throughput

0.445

High

614696

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

7

High-throughput

0.445

High

614723

MF14A
Hippocampus abundant transcript 1 protein

1

4

High-throughput

0.445

High

105294

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

137953

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.437

High

220857

XPOT
Exportin-T

1

13

High-throughput

0.437

High

614670

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

2

High-throughput

0.437

High

614694

NHSL1
NHS-like protein 1

1

7

High-throughput

0.437

High

614720

SAAL1
Protein SAAL1

1

4

High-throughput

0.437

High

614731

XPO4
Exportin-4

1

7

High-throughput

0.437

High

614735

XPO5
Exportin-5

1

14

High-throughput

0.437

High

614738

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.437

High

614746

TNPO3
Transportin-3

1

15

High-throughput

0.437

High

614749

NUMBL
Numb-like protein

1

4

High-throughput

0.437

High

64851

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.426

High

574076

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

0

High-throughput

0.426

High

252822

EXOC3
Exocyst complex component 3

2

0

High-throughput

0.305

High

614722

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

614682

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.279

Low

614697

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.279

Low

614740

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.279

Low

614674

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.265

Low

614668

RD23B
UV excision repair protein RAD23 homolog B

1

0

High-throughput

0.249

Low

614707

PHAR4
Phosphatase and actin regulator 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025