HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 19058874, 24623782, 12697810, 27884160, 10757792, 11266467, 21675959, 21336309, 11823456, 11352917, 11279118, 34965427, 12788955, 17255949, 23241949
Identification Methods affinity chromatography technology, pull down, protein complementation assay, enzymatic study, two hybrid, anti bait coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005769 - early endosome
and 23 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 360
Hs

1 393
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+ At
+ At
+ Dm
+ At
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+ At
+ Hs
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024