Protein: SPNS1
Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1)

Gene: SPNS1
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9H2V7

Gene Ontology (top 5):
GO:0005743 - mitochondrial inner membrane
GO:0005765 - lysosomal membrane
GO:0016020 - membrane
GO:0022857 - transmembrane transporter activity
GO:0033700 - phospholipid efflux

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1432221

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.691

High

777765

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.578

High

1157065

NTRK3
NT-3 growth factor receptor

1

3

High-throughput

0.578

High

182769

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

226364

SNG1
Synaptogyrin-1

1

1

High-throughput

0.536

High

380484

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.536

High

634804

GRAH
Granzyme H

1

1

High-throughput

0.536

High

1363227

AQP3
Aquaporin-3

1

2

High-throughput

0.536

High

1432218

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.536

High

1432219

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.536

High

709255

AA2AR
Adenosine receptor A2a

1

0

High-throughput

0.518

High

522134

BCL2
Apoptosis regulator Bcl-2

1

1

Small-scale

0.515

High

1060226

B2CL1
Bcl-2-like protein 1

1

1

Small-scale

0.515

High

1201828

SDK2
Protein sidekick-2

1

1

High-throughput

0.514

High

1416521

JAM3
Junctional adhesion molecule C

1

1

High-throughput

0.514

High

1350065

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1432222

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.513

High

719514

BKRB2
B2 bradykinin receptor

1

2

High-throughput

0.494

High

907078

CCR8
C-C chemokine receptor type 8

1

2

High-throughput

0.494

High

907115

CCR9
C-C chemokine receptor type 9

1

2

High-throughput

0.494

High

166041

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

841582

I12R1
Interleukin-12 receptor subunit beta-1

1

2

High-throughput

0.489

High

1090113

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

2

High-throughput

0.489

High

1291893

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.489

High

1432108

KLK15
Kallikrein-15

1

1

High-throughput

0.489

High

1432212

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.489

High

363845

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

562390

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

975238

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

1233477

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1308211

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1432211

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.479

High

1432217

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

178394

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

284415

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

488863

FURIN
Furin

1

0

High-throughput

0.458

High

800097

COIL
Coilin

1

0

High-throughput

0.458

High

1114278

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1178371

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1314546

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

1418442

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1432213

RRBP1
Ribosome-binding protein 1

1

0

High-throughput

0.458

High

412599

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.457

High

608189

PYRG1
CTP synthase 1

1

1

High-throughput

0.445

High

1151871

RHOH
Rho-related GTP-binding protein RhoH

1

1

High-throughput

0.437

High

1163899

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.437

High

1307925

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.437

High

1432210

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.437

High

1432216

TES
Testin

1

2

High-throughput

0.437

High

380142

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

869669

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

0

High-throughput

0.426

High

1393203

TM169
Transmembrane protein 169

1

0

High-throughput

0.426

High

322995

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

1

High-throughput

0.407

High

593003

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

1348724

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

2

High-throughput

0.407

High

1380910

RAB24
Ras-related protein Rab-24

1

2

High-throughput

0.407

High

1416018

SYTM
Threonine--tRNA ligase, mitochondrial

1

3

High-throughput

0.407

High

1432220

NOTC3
Neurogenic locus notch homolog protein 3

1

2

High-throughput

0.407

High

477176

ACM5
Muscarinic acetylcholine receptor M5

1

0

High-throughput

0.282

High

702844

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.282

High

260955

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

749395

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

1239296

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

1289018

NLRX1
NLR family member X1

1

0

High-throughput

0.279

Low

1310398

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1399609

OPALI
Opalin

1

0

High-throughput

0.279

Low

1432208

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1432209

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.279

Low

1430947

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.269

Low

242903

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

294320

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

414604

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

769154

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879460

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

905135

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

962469

RHOA
Transforming protein RhoA

1

0

High-throughput

0.249

Low

1215824

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

1252444

M3K15
Mitogen-activated protein kinase kinase kinase 15

1

0

High-throughput

0.249

Low

1286903

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

1383244

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1432207

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

885507

MA2A2
Alpha-mannosidase 2x

1

0

High-throughput

0.232

Low

1210619

SYVM
Valine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1406566

METH
Methionine synthase

1

0

High-throughput

0.232

Low

1432214

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.232

Low

1432215

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.232

Low

1432223

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025