HitPredict

Interactor 1: BDNF (P23560)
Neurotrophic factor BDNF precursor form (proBDNF) (Abrineurin) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF]
Gene: BDNF

Interactor 2: NTF4 (P34130)
Neurotrophin-4 (NT-4) (Neurotrophin-5) (NT-5) (Neutrophic factor 4)
Gene: NTF4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

The method score is based on:

Property	Details
Experiments	29997244, 10631974
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, luminescence based mammalian interactome mapping, x-ray crystallography
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	NGF~NGF
Common GO terms	GO:0005163 - nerve growth factor receptor binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0008021 - synaptic vesicle and 8 others more... GO:0008083 - growth factor activity GO:0021675 - nerve development GO:0030424 - axon GO:0030425 - dendrite GO:0038180 - nerve growth factor signaling pathway GO:0043524 - negative regulation of neuron apoptotic process GO:0048812 - neuron projection morphogenesis GO:0050804 - modulation of chemical synaptic transmission
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	247
Hs

1	210

Service provided by Combinatics, Japan

Last updated: 11Aug2025