HitPredict

Interactor 1: GRN (P28799)
Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Gene: GRN

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 772
+	Hs
		660469 GRN_HUMAN (1-593): 0: 726: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		660474 GRN_HUMAN (1-593): 0: 726: 100.00		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		660457 GRN_HUMAN (1-593): 0: 726: 100.00		GBB2_HUMAN (688-771): 3.6e-14: 76.4: 16.47
+	Hs
		660656 GRN_HUMAN (1-593): 0: 726: 100.00		SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52