HitPredict

Interactor 1: CXB2 (P29033)
Gap junction beta-2 protein (Connexin-26) (Cx26)
Gene: GJB2

Interactor 2: CXA3 (Q9Y6H8)
Gap junction alpha-3 protein (Connexin-46) (Cx46)
Gene: GJA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Connexin~Connexin
Common GO terms	GO:0005243 - gap junction channel activity GO:0005886 - plasma membrane GO:0005922 - connexin complex GO:0007267 - cell-cell signaling GO:1990349 - gap junction-mediated intercellular transport
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 435
+	Hs
		661149 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXA8_HUMAN (1-435): 0: 574: 44.60
+	Rn
		435243 CXB2_RAT (1-226): 5.35e-126: 357: 93.81		CXA1_RAT (1-352): 1.25e-163: 467: 43.80
+	Hs
		566966 CXA8_HUMAN (2-226): 1.61e-120: 350: 51.46		CXA1_HUMAN (1-352): 7.15e-164: 468: 43.53
+	Hs
		567354 CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26		CXA1_HUMAN (1-352): 7.15e-164: 468: 43.53
+	Hs
		566913 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXA1_HUMAN (1-352): 7.15e-164: 468: 43.53
+	Hs
		661144 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXB2_HUMAN (3-237): 6.37e-121: 352: 48.73
+	Hs
		661148 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXA5_HUMAN (1-435): 8.86e-119: 352: 38.95
+	Hs
		434815 CXB2_HUMAN (1-226): 1.37e-126: 358: 100.00		CXB1_HUMAN (3-242): 1.12e-115: 341: 45.23
+	Mm
		657011 CXB2_MOUSE (1-226): 2.71e-125: 355: 92.92		CXB3_MOUSE (3-236): 1.48e-115: 341: 41.53
+	Hs
		734430 CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26		CXG1_HUMAN (4-380): 6.29e-121: 359: 34.54
+	Mm
		657010 CXB6_MOUSE (1-224): 2.46e-121: 346: 78.13		CXB3_MOUSE (3-236): 1.48e-115: 341: 41.53
+	Hs
		566949 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXG1_HUMAN (4-380): 6.29e-121: 359: 34.54
+	Mm
		613301 CXA1_MOUSE (2-223): 7.11e-105: 309: 43.33		CXG1_MOUSE (4-258): 1.09e-120: 358: 42.71
+	Hs
		566948 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXA5_HUMAN (1-435): 8.86e-119: 352: 38.95
+	Hs
		274164 CXA3_HUMAN (2-219): 3.79e-112: 329: 48.26		CXB3_HUMAN (3-242): 1.8e-110: 327: 39.26
+	Hs
		567163 CXA1_HUMAN (2-223): 1.34e-105: 311: 43.75		CXD3_HUMAN (1-233): 1.19e-96: 293: 40.77