Protein: SPT6H
Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)

Gene: SPT6H, SUPT6H
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q7KZ85

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0006368 - transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

130523

SPT5H
Transcription elongation factor SPT5

3

4

High-throughput

0.861

High

667353

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

5

Small-scale

0.834

High

967818

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

5

High-throughput

0.789

High

997818

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.710

High

192831

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.691

High

339997

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

5

High-throughput

0.691

High

723006

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.691

High

1006493

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.691

High

1154383

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.691

High

1270336

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

4

4

High-throughput

0.691

High

621905

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

2

High-throughput

0.675

High

1270343

PIHD1
PIH1 domain-containing protein 1

4

0

High-throughput

0.664

High

912199

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

1

High-throughput

0.650

High

728309

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.647

High

958977

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

0

High-throughput

0.638

High

396394

ESR1
Estrogen receptor

3

7

Small-scale

0.633

High

591704

H2AX
Histone H2AX

2

7

High-throughput

0.628

High

1065257

SSRP1
FACT complex subunit SSRP1

2

5

High-throughput

0.628

High

1270327

IWS1
Protein IWS1 homolog

2

5

Small-scale

0.624

High

262532

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.618

High

786693

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.618

High

621675

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

4

Small-scale

0.611

High

983670

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.611

High

1270296

SKAP1
Src kinase-associated phosphoprotein 1

2

5

High-throughput

0.611

High

1270314

DDB2
DNA damage-binding protein 2

2

7

High-throughput

0.611

High

1270304

TTC29
Tetratricopeptide repeat protein 29

3

1

High-throughput

0.609

High

410915

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

3

High-throughput

0.602

High

681847

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

1270349

UXT
Protein UXT

2

0

High-throughput

0.602

High

1270352

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.602

High

1109309

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.601

High

654650

TCEA1
Transcription elongation factor A protein 1

2

3

Small-scale

0.595

High

923509

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

414085

P53
Cellular tumor antigen p53

2

3

High-throughput

0.584

High

998474

H31
Histone H3.1

2

10

High-throughput

0.584

High

1270351

ZRAN1
Ubiquitin thioesterase ZRANB1

2

4

High-throughput

0.584

High

1209308

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.575

High

1270316

ESR2
Estrogen receptor beta

2

7

High-throughput

0.571

High

132120

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

4

High-throughput

0.558

High

157536

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.553

High

335474

SLU7
Pre-mRNA-splicing factor SLU7

1

2

High-throughput

0.536

High

478097

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

480201

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

481320

HMGB1
High mobility group protein B1

1

7

High-throughput

0.536

High

542084

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

574338

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

682531

S100P
Protein S100-P

1

1

High-throughput

0.536

High

775165

FUS
RNA-binding protein FUS

1

1

High-throughput

0.536

High

884136

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

912078

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.536

High

973959

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.536

High

1016976

H33
Histone H3.3

1

10

High-throughput

0.536

High

1145244

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.536

High

1160179

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.536

High

1163012

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

1243815

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.536

High

1270301

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

7

High-throughput

0.536

High

1270305

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.536

High

1270309

WDR48
WD repeat-containing protein 48

1

5

High-throughput

0.536

High

1270322

DCAF5
DDB1- and CUL4-associated factor 5

1

5

High-throughput

0.536

High

1270325

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

4

High-throughput

0.536

High

1270340

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.536

High

1270356

RUVB2
RuvB-like 2

1

8

High-throughput

0.536

High

1270357

RUVB1
RuvB-like 1

1

8

High-throughput

0.536

High

1270358

STRAP
Serine-threonine kinase receptor-associated protein

1

5

High-throughput

0.536

High

506016

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

0

High-throughput

0.528

High

274640

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.518

High

1270323

H2A1H
Histone H2A type 1-H

1

6

High-throughput

0.515

High

284328

GEMI
Geminin

1

0

High-throughput

0.513

High

837683

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

1204366

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1270308

CTCFL
Transcriptional repressor CTCFL

1

0

High-throughput

0.513

High

1270321

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

1270341

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

573542

ENPL
Endoplasmin

1

2

Small-scale

0.501

High

801387

HSPA9
Stress-70 protein, mitochondrial

1

6

Small-scale

0.501

High

1042885

ERCC6
DNA excision repair protein ERCC-6

1

10

High-throughput

0.501

High

161822

RIOK3
Serine/threonine-protein kinase RIO3

1

2

High-throughput

0.489

High

347131

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

945582

FBXW4
F-box/WD repeat-containing protein 4

1

6

High-throughput

0.489

High

984175

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.489

High

1179001

S35G1
Solute carrier family 35 member G1

1

1

High-throughput

0.489

High

1256445

K0408
Uncharacterized protein KIAA0408

1

1

High-throughput

0.489

High

1270298

CCD71
Coiled-coil domain-containing protein 71

1

1

High-throughput

0.489

High

1270332

RPAP3
RNA polymerase II-associated protein 3

1

5

High-throughput

0.489

High

1270346

WSB2
WD repeat and SOCS box-containing protein 2

1

5

High-throughput

0.489

High

532705

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.480

High

138189

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

180857

TIF1A
Transcription intermediary factor 1-alpha

1

10

Small-scale

0.479

High

190970

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

216474

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.479

High

260111

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

272698

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

3

Small-scale

0.479

High

277723

H2AY
Core histone macro-H2A.1

1

7

High-throughput

0.479

High

285338

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

316296

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.479

High

316406

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

Small-scale

0.479

High

317191

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

326351

SCAF4
SR-related and CTD-associated factor 4

1

2

High-throughput

0.479

High

370708

FOS
Protein c-Fos

1

3

High-throughput

0.479

High

372393

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

419045

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

487461

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

588995

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

695783

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

714902

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

731412

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

765648

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.479

High

768498

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

799232

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

799950

COIL
Coilin

1

2

High-throughput

0.479

High

830958

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

904866

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

934780

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

948510

ELOF1
Transcription elongation factor 1 homolog

1

2

Small-scale

0.479

High

979880

H4
Histone H4

1

7

High-throughput

0.479

High

990403

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.479

High

1067455

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1088413

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

13

High-throughput

0.479

High

1106345

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

1106971

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1113500

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1124358

ELOA1
Elongin-A

1

4

Small-scale

0.479

High

1129635

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.479

High

1132779

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

13

High-throughput

0.479

High

1155490

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

1217587

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

4

High-throughput

0.479

High

1217874

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

3

Small-scale

0.479

High

1235451

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1270302

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1270303

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1270307

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1270318

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1270320

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

1270329

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1270333

SFR19
Splicing factor, arginine/serine-rich 19

1

2

High-throughput

0.479

High

1270334

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

1

High-throughput

0.479

High

1270338

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1270339

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1270345

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1270347

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1270354

BAZ1B
Tyrosine-protein kinase BAZ1B

1

10

Small-scale

0.479

High

1270359

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

1270360

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

535230

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.470

High

600841

HSP76
Heat shock 70 kDa protein 6

1

3

High-throughput

0.470

High

1270306

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

331080

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

566730

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.458

High

808103

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

894847

EMD
Emerin

1

0

High-throughput

0.458

High

984830

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1026439

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1153824

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1270299

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.458

High

1270300

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1270317

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1270326

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1270350

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1270355

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

363475

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.457

High

890847

TSC2
Tuberin

1

2

Small-scale

0.457

High

409431

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

853318

CBX5
Chromobox protein homolog 5

1

6

Small-scale

0.445

High

1270335

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

242090

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.437

High

272279

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

655852

TBG1
Tubulin gamma-1 chain

1

2

High-throughput

0.437

High

942703

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.437

High

954965

S10AA
Protein S100-A10

1

1

Small-scale

0.437

High

1134963

CUL7
Cullin-7

1

2

High-throughput

0.437

High

1254363

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1270295

PHLB2
Pleckstrin homology-like domain family B member 2

1

9

High-throughput

0.437

High

1270312

PARD3
Partitioning defective 3 homolog

1

3

High-throughput

0.437

High

1270328

PAAF1
Proteasomal ATPase-associated factor 1

1

6

Small-scale

0.437

High

1270330

CP250
Centrosome-associated protein CEP250

1

5

High-throughput

0.437

High

1270344

S39A1
Zinc transporter ZIP1

1

4

High-throughput

0.437

High

1270348

PHRF1
PHD and RING finger domain-containing protein 1

1

8

High-throughput

0.437

High

505958

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

1199543

KLH22
Kelch-like protein 22

1

2

High-throughput

0.407

High

1231990

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

1231718

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

1270313

TB22A
TBC1 domain family member 22A

3

0

High-throughput

0.347

High

963318

PFD3
Prefoldin subunit 3

2

0

High-throughput

0.328

High

1005367

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.292

High

1106486

GAB1
GRB2-associated-binding protein 1

1

0

High-throughput

0.279

Low

224495

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

505174

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

813135

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

1059119

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

1187722

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.279

Low

1199912

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

1231430

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1270311

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

1270315

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

1270324

RN145
RING finger protein 145

1

0

High-throughput

0.279

Low

1270337

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.279

Low

1270353

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

178642

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

1270297

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.249

Low

1270310

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.249

Low

1270319

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.249

Low

1270342

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.249

Low

1270331

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025