HitPredict

Interactor 1: PTN4 (P29074)
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)
Gene: PTPN4

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27432908, 28675297
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~SH3_2, SH2~Y_phosphatase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Hs			1 303
+	Hs
		663965 PTN4_HUMAN (1-926): 0: 949: 100.00		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		557617 PTN4_HUMAN (1-926): 0: 949: 100.00		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		663972 PTN4_HUMAN (1-926): 0: 949: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		802784 E41L3_HUMAN (21-682): 1.53e-132: 427: 27.22		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Ce
		104061 G5EBP4_CAEEL (10-509): 1.04e-129: 434: 28.30		SEM5_CAEEL (126-302): 2.88e-25: 102: 16.44
+	Ce
		106817 G5EEG8_CAEEL (10-509): 1.32e-129: 434: 28.30		SEM5_CAEEL (126-302): 2.88e-25: 102: 16.44
+	Hs
		580938 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		562628 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10
+	Mm
		250716 E41L2_MOUSE (18-510): 1.54e-124: 403: 33.40		PLCG2_MOUSE (5-192): 3.94e-27: 113: 18.72
+	Hs
		299283 FARP2_HUMAN (8-507): 5.08e-133: 427: 34.40		Q96D37_HUMAN (214-293): 2.34e-15: 78.3: 30.86
+	Hs
		299235 FARP2_HUMAN (8-507): 5.08e-133: 427: 34.40		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		576998 PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		548649 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		616905 PTPRB_HUMAN (334-925): 1.77e-123: 415: 23.64		CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40
+	Hs
		665853 PTN6_HUMAN (546-913): 1.07e-134: 417: 32.46		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		577009 PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Mm
		574006 PTPRA_MOUSE (639-912): 1.11e-95: 321: 33.45		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32
+	Hs
		208991 PTPRA_HUMAN (639-912): 7.66e-96: 321: 33.45		NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48
+	Hs
		782790 PTPRK_HUMAN (643-914): 1.01e-55: 212: 27.72		CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40
+	Hs
		146925 PTPRT_HUMAN (649-914): 3.08e-55: 210: 28.21		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32