HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, I-set~fn3, fn3~ig, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0019838 - growth factor binding GO:0030335 - positive regulation of cell migration and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 1363
+	Hs
		665144 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87
+	Hs
		665184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA5_HUMAN (373-1199): 1.28e-153: 493: 13.44
+	Hs
		665244 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA7_HUMAN (392-1212): 1.3e-153: 492: 14.29
+	Hs
		665142 EPHA2_HUMAN (1-976): 0: 1141: 100.00		EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15
+	Hs
		665605 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHB2_HUMAN (372-1320): 3.34e-154: 495: 12.87
+	Hs
		665399 EPHA7_HUMAN (4-974): 0: 1128: 50.30		EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15
+	Hs
		665383 EPHA5_HUMAN (11-976): 0: 1127: 51.34		EPHA3_HUMAN (386-1200): 1.47e-152: 489: 14.15
+	Mm
		872618 EPHA4_MOUSE (1-976): 0: 1126: 50.45		EPHB2_MOUSE (372-1266): 9.54e-153: 489: 12.98
+	Hs
		452362 EPHA2_HUMAN (1-976): 0: 1141: 100.00		PGFRB_HUMAN (19-555): 1.14e-123: 413: 22.80
+	Hs
		557042 EPHA2_HUMAN (1-976): 0: 1141: 100.00		PGFRA_HUMAN (11-549): 8.68e-55: 211: 20.36
+	Hs
		609184 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR3_HUMAN (310-670): 4.9e-27: 121: 13.53
+	Hs
		426987 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CSF1R_HUMAN (1-337): 2.83e-23: 109: 10.87
+	Hs
		426999 EPHA7_HUMAN (4-974): 0: 1128: 50.30		CSF1R_HUMAN (1-337): 2.83e-23: 109: 10.87
+	Hs
		607887 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		507871 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		601465 EPHA2_HUMAN (1-976): 0: 1141: 100.00		FGFR2_HUMAN (2-160): 1e-11: 71.9: 14.12
+	Hs
		607974 EPHA7_HUMAN (4-974): 0: 1128: 50.30		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		607929 EPHA4_HUMAN (1-976): 0: 1121: 50.25		FGFR4_HUMAN (535-810): 1.64e-14: 80.8: 15.79
+	Hs
		507926 EPHA4_HUMAN (1-976): 0: 1121: 50.25		FGFR1_HUMAN (2-160): 6.17e-14: 78.9: 11.93
+	Hs
		601484 EPHA4_HUMAN (1-976): 0: 1121: 50.25		FGFR2_HUMAN (2-160): 1e-11: 71.9: 14.12