Protein: UBP48
Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)

Gene: UBP48, USP48
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q86UV5

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508221

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

20

Small-scale

0.907

High

507255

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

20

Small-scale

0.861

High

1289109

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

17

Small-scale

0.789

High

1289085

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

14

Small-scale

0.754

High

1289104

WDR76
WD repeat-containing protein 76

2

19

Small-scale

0.754

High

998493

H31
Histone H3.1

4

10

Small-scale

0.676

High

449746

H2B1J
Histone H2B type 1-J

3

20

Small-scale

0.667

High

1220611

RN123
E3 ubiquitin-protein ligase RNF123

3

11

Small-scale

0.667

High

1280987

PXK
PX domain-containing protein kinase-like protein

3

8

Small-scale

0.667

High

1289102

UBAC1
Ubiquitin-associated domain-containing protein 1

3

4

Small-scale

0.667

High

1289110

ZN232
Zinc finger protein 232

3

9

Small-scale

0.667

High

1045463

TF65
Transcription factor p65

3

10

Small-scale

0.664

High

1134828

NR1D2
Nuclear receptor subfamily 1 group D member 2

3

10

Small-scale

0.656

High

591716

H2AX
Histone H2AX

3

19

Small-scale

0.640

High

980888

H2B1C
Histone H2B type 1-C/E/F/G/I

3

20

Small-scale

0.640

High

1090756

TRAF2
TNF receptor-associated factor 2

3

20

Small-scale

0.640

High

1289089

SIR6
NAD-dependent protein deacylase sirtuin-6

3

13

Small-scale

0.640

High

1272307

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

3

0

Small-scale

0.638

High

466680

GLI1
Zinc finger protein GLI1

2

12

Small-scale

0.624

High

1289095

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.618

High

422467

A4
Amyloid-beta precursor protein

2

6

Small-scale

0.595

High

997828

CSK21
Casein kinase II subunit alpha

2

8

Small-scale

0.595

High

1111077

SNW1
SNW domain-containing protein 1

2

0

Small-scale

0.585

High

277729

H2AY
Core histone macro-H2A.1

2

20

Small-scale

0.584

High

412190

NTRK1
High affinity nerve growth factor receptor

2

11

Small-scale

0.584

High

419058

H2A1B
Histone H2A type 1-B/E

2

17

Small-scale

0.584

High

502038

H2AZ
Histone H2A.Z

2

19

Small-scale

0.584

High

754896

H2B1B
Histone H2B type 1-B

2

20

Small-scale

0.584

High

832740

BCL6
B-cell lymphoma 6 protein

2

7

Small-scale

0.584

High

891654

GSK3B
Glycogen synthase kinase-3 beta

2

6

Small-scale

0.584

High

979912

H4
Histone H4

2

7

Small-scale

0.584

High

1028266

MDM2
E3 ubiquitin-protein ligase Mdm2

2

9

Small-scale

0.584

High

1094366

CSN1
COP9 signalosome complex subunit 1

2

4

Small-scale

0.584

High

771636

DRD3
D(3) dopamine receptor

2

4

Small-scale

0.566

High

155679

FCHO1
F-BAR domain only protein 1

1

4

High-throughput

0.536

High

1289094

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1289099

FMNL2
Formin-like protein 2

1

1

High-throughput

0.536

High

877688

SL9A3
Sodium/hydrogen exchanger 3

2

6

Small-scale

0.533

High

1096079

TADBP
TAR DNA-binding protein 43

1

13

High-throughput

0.515

High

964353

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

191481

CCL16
C-C motif chemokine 16

1

2

High-throughput

0.489

High

1289090

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

48366

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

4

Small-scale

0.479

High

123405

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

190979

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

8

High-throughput

0.479

High

218402

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

248901

GSDME
Gasdermin-E

1

1

Small-scale

0.479

High

260135

BRD4
Bromodomain-containing protein 4

1

16

High-throughput

0.479

High

367554

CAH1
Carbonic anhydrase 1

1

3

Small-scale

0.479

High

424220

S10A8
Protein S100-A8

1

10

Small-scale

0.479

High

445018

S10A9
Protein S100-A9

1

11

Small-scale

0.479

High

459655

PROF1
Profilin-1

1

3

Small-scale

0.479

High

474100

NFIC
Nuclear factor 1 C-type

1

10

High-throughput

0.479

High

479840

GSTP1
Glutathione S-transferase P

1

6

Small-scale

0.479

High

487480

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.479

High

520176

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

575797

MMP9
Matrix metalloproteinase-9

1

5

Small-scale

0.479

High

578605

CBPA3
Mast cell carboxypeptidase A

1

2

Small-scale

0.479

High

583877

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

7

Small-scale

0.479

High

589059

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

595498

H15
Histone H1.5

1

12

Small-scale

0.479

High

596203

H12
Histone H1.2

1

11

Small-scale

0.479

High

663558

CMA1
Chymase

1

8

Small-scale

0.479

High

688056

EF1G
Elongation factor 1-gamma

1

6

High-throughput

0.479

High

695848

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

768557

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

788699

SRP14
Signal recognition particle 14 kDa protein

1

1

Small-scale

0.479

High

799255

BRCA1
Breast cancer type 1 susceptibility protein

1

15

Small-scale

0.479

High

809704

RS19
Small ribosomal subunit protein eS19

1

1

Small-scale

0.479

High

810192

RL3
Large ribosomal subunit protein uL3

1

3

Small-scale

0.479

High

858972

RL27A
Large ribosomal subunit protein uL15

1

1

Small-scale

0.479

High

883597

CENPA
Histone H3-like centromeric protein A

1

10

High-throughput

0.479

High

911628

NCBP2
Nuclear cap-binding protein subunit 2

1

9

Small-scale

0.479

High

927386

ATX1
Ataxin-1

1

4

High-throughput

0.479

High

970722

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

975786

RL7A
Large ribosomal subunit protein eL8

1

6

Small-scale

0.479

High

1016990

H33
Histone H3.3

1

10

High-throughput

0.479

High

1037241

H11
Histone H1.1

1

11

Small-scale

0.479

High

1087841

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

1105145

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.479

High

1115278

CUL4B
Cullin-4B

1

11

Small-scale

0.479

High

1119629

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

1

Small-scale

0.479

High

1128044

DHX8
ATP-dependent RNA helicase DHX8

1

12

Small-scale

0.479

High

1133505

NFIX
Nuclear factor 1 X-type

1

10

High-throughput

0.479

High

1162818

H2A2C
Histone H2A type 2-C

1

17

Small-scale

0.479

High

1198961

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

2

Small-scale

0.479

High

1214637

RBM26
RNA-binding protein 26

1

10

Small-scale

0.479

High

1275539

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

9

Small-scale

0.479

High

1288129

ZN329
Zinc finger protein 329

1

3

Small-scale

0.479

High

1289086

HTR5A
HEAT repeat-containing protein 5A

1

1

Small-scale

0.479

High

1289091

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.479

High

1289096

AURKB
Aurora kinase B

1

13

Small-scale

0.479

High

1289097

ZFR
Zinc finger RNA-binding protein

1

10

Small-scale

0.479

High

1289100

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.479

High

1289103

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

12

Small-scale

0.479

High

1289105

CSN7B
COP9 signalosome complex subunit 7b

1

2

Small-scale

0.479

High

1289107

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

Small-scale

0.479

High

1289111

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1289112

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

1

Small-scale

0.479

High

319106

SC24D
Protein transport protein Sec24D

1

0

Small-scale

0.458

High

361036

PH4H
Phenylalanine-4-hydroxylase

1

0

Small-scale

0.458

High

567017

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

Small-scale

0.458

High

585458

VEGFA
Vascular endothelial growth factor A, long form

1

0

Small-scale

0.458

High

590990

LOX15
Polyunsaturated fatty acid lipoxygenase ALOX15

1

0

Small-scale

0.458

High

622740

GGT1
Glutathione hydrolase 1 proenzyme

1

0

Small-scale

0.458

High

857339

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

Small-scale

0.458

High

1210346

NU188
Nucleoporin NUP188

1

0

Small-scale

0.458

High

1245199

BRAT1
Integrator complex assembly factor BRAT1

1

0

Small-scale

0.458

High

1289088

PROM2
Prominin-2

1

0

Small-scale

0.458

High

1289092

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1289108

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1289098

CEP63
Centrosomal protein of 63 kDa

1

18

High-throughput

0.457

High

372456

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.445

High

1130322

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

6

High-throughput

0.445

High

1237992

Q6NSM0
NR1D2 protein

1

14

High-throughput

0.445

High

106202

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

366185

HPT
Haptoglobin

1

7

Small-scale

0.437

High

369264

ANT3
Antithrombin-III

1

7

Small-scale

0.437

High

384259

CO2A1
Collagen alpha-1(II) chain

1

1

Small-scale

0.437

High

416963

CY24B
NADPH oxidase 2

1

2

Small-scale

0.437

High

420010

B3A2
Anion exchange protein 2

1

2

Small-scale

0.437

High

430721

TETN
Tetranectin

1

3

Small-scale

0.437

High

458698

SAP
Prosaposin

1

1

Small-scale

0.437

High

567904

PRG2
Bone marrow proteoglycan

1

3

Small-scale

0.437

High

632933

PRVA
Parvalbumin alpha

1

1

Small-scale

0.437

High

756564

GALNS
N-acetylgalactosamine-6-sulfatase

1

1

Small-scale

0.437

High

847584

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.437

High

852673

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

5

Small-scale

0.437

High

895594

SERPH
Serpin H1

1

8

Small-scale

0.437

High

939511

FCGRN
IgG receptor FcRn large subunit p51

1

3

Small-scale

0.437

High

1009673

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

Small-scale

0.437

High

1087062

FSTL1
Follistatin-related protein 1

1

2

Small-scale

0.437

High

1154999

ADIPO
Adiponectin

1

3

Small-scale

0.437

High

1289093

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

2

Small-scale

0.437

High

1289101

GBRG3
Gamma-aminobutyric acid receptor subunit gamma-3

1

2

Small-scale

0.437

High

1289106

DJC17
DnaJ homolog subfamily C member 17

1

13

High-throughput

0.437

High

467024

DAF
Complement decay-accelerating factor

1

0

Small-scale

0.249

Low

1042643

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.249

Low

1289087

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025