HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: RND3 (P61587)
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Gene: RND3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007155 - cell adhesion GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 244
+	Hs
		665177 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RND2_HUMAN (20-244): 3.9e-103: 300: 64.00
+	Hs
		436169 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48
+	Hs
		665301 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RND1_HUMAN (1-244): 1.22e-90: 268: 58.20
+	Hs
		665198 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84
+	Hs
		436317 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOC_HUMAN (22-213): 2.02e-92: 271: 49.48
+	Hs
		915694 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84
+	Hs
		665192 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00
+	Hs
		665201 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC1_HUMAN (24-210): 3.03e-80: 240: 43.32
+	Hs
		545218 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC2_HUMAN (24-211): 1.42e-76: 231: 39.89
+	Hs
		665194 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOA_HUMAN (25-207): 1.21e-76: 231: 50.27
+	Hs
		665191 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75
+	Hs
		925297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC1_HUMAN (24-210): 3.03e-80: 240: 43.32
+	Hs
		665208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOG_HUMAN (23-208): 1.85e-74: 226: 42.47
+	Hs
		545394 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC2_HUMAN (24-211): 1.42e-76: 231: 39.89
+	Hs
		900497 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOA_HUMAN (25-207): 1.21e-76: 231: 50.27
+	Hs
		892388 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75
+	Hs
		120312 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOD_HUMAN (25-211): 1.61e-54: 176: 41.18
+	Hs
		665335 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOF_HUMAN (25-212): 1.18e-52: 171: 45.21
+	Hs
		564420 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOQ_HUMAN (25-212): 8.64e-51: 166: 42.02
+	Hs
		564541 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOQ_HUMAN (25-212): 8.64e-51: 166: 42.02