HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016477 - cell migration GO:0030027 - lamellipodium GO:0032587 - ruffle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 193
+	Hs
		665201 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		436169 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		665208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		665192 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545218 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		900497 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		665191 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		665198 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		436317 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		436223 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		951011 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		872419 EPHA5_HUMAN (11-976): 0: 1127: 51.34		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545394 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		545285 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		120312 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		892388 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		872418 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		915694 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120363 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98