HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: STYX (Q8WUJ0)
Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Gene: STYX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DSPc~fn3
Common GO terms	GO:0070372 - regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 223
+	Hs
		1072561 EPHA7_HUMAN (4-974): 0: 1128: 50.30		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		665415 EPHA3_HUMAN (24-976): 0: 1111: 51.19		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		304919 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		665288 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		665264 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DUS29_HUMAN (22-174): 2.63e-56: 180: 30.77
+	Hs
		665322 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DUS26_HUMAN (27-176): 1.44e-56: 180: 30.46
+	Hs
		665295 EPHA2_HUMAN (1-976): 0: 1141: 100.00		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		1072555 EPHA7_HUMAN (4-974): 0: 1128: 50.30		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		1072585 EPHA7_HUMAN (4-974): 0: 1128: 50.30		DUS26_HUMAN (27-176): 1.44e-56: 180: 30.46
+	Hs
		872488 EPHA5_HUMAN (11-976): 0: 1127: 51.34		DUS21_HUMAN (19-185): 6.37e-55: 175: 26.95
+	Hs
		665410 EPHA3_HUMAN (24-976): 0: 1111: 51.19		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		665430 EPHA3_HUMAN (24-976): 0: 1111: 51.19		DUS21_HUMAN (19-185): 6.37e-55: 175: 26.95
+	Hs
		304915 EPHA1_HUMAN (17-967): 0: 959: 49.38		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		171316 EPHB6_HUMAN (28-962): 0: 871: 37.66		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		171313 EPHB6_HUMAN (28-962): 0: 871: 37.66		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		171315 EPHB6_HUMAN (28-962): 0: 871: 37.66		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97
+	Hs
		537762 INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55		STYX_HUMAN (1-223): 9.96e-91: 267: 100.00
+	Hs
		304907 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		DUS14_HUMAN (7-185): 4.2e-63: 196: 31.84
+	Hs
		411444 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		DUS18_HUMAN (10-185): 5.17e-58: 183: 26.71
+	Hs
		411449 INSR_HUMAN (281-933): 1.71e-136: 445: 24.85		DUS19_HUMAN (32-187): 5.31e-55: 176: 33.97