Interactor 1: PTN6 (P29351)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
Gene: Ptpn6

Interactor 2: SHPS1 (P97797)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
Gene: Sirpa

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.60 0.640

The method score is based on:

Property Details
Experiments 18233962, 17954568, 16920950
Identification Methods anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002244 - hematopoietic progenitor cell differentiation
GO:0017124 - SH3 domain binding
GO:0032715 - negative regulation of interleukin-6 production
GO:0032720 - negative regulation of tumor necrosis factor production
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 595
Mm

1 513
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024