HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: S10A7 (P31151)
Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)
Gene: S100A7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 583 Hs			1 101
+	Hs
		416356 SHC1_HUMAN (1-583): 0: 531: 100.00		S10A9_HUMAN (4-101): 4.09e-28: 99: 23.53
+	Hs
		416576 SHC1_HUMAN (1-583): 0: 531: 100.00		S10A6_HUMAN (2-92): 4.58e-23: 86.5: 23.40
+	Hs
		396686 SHC1_HUMAN (1-583): 0: 531: 100.00		S10A8_HUMAN (2-94): 6.39e-23: 86.1: 22.92
+	Hs
		380729 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		S100B_HUMAN (4-93): 2.11e-25: 92.3: 24.73
+	Hs
		678424 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		S10A7_HUMAN (1-101): 8.48e-31: 106: 100.00
+	Hs
		661266 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		S10A2_HUMAN (1-92): 3.45e-28: 99.6: 22.11
+	Mm
		140056 P85B_MOUSE (358-581): 2.77e-30: 128: 16.67		S10AA_MOUSE (2-90): 1.28e-31: 108: 24.72
+	Hs
		678499 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		S10A7_HUMAN (1-101): 8.48e-31: 106: 100.00
+	Hs
		639060 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		S100P_HUMAN (4-93): 5.29e-30: 104: 26.88
+	Hs
		1125343 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		FILA2_HUMAN (4-101): 1.48e-26: 103: 23.76
+	Hs
		416505 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		S10A9_HUMAN (4-101): 4.09e-28: 99: 23.53
+	Hs
		416396 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		S10A9_HUMAN (4-101): 4.09e-28: 99: 23.53
+	Hs
		396795 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		S10A8_HUMAN (2-94): 6.39e-23: 86.1: 22.92
+	Hs
		596312 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		FILA_HUMAN (4-101): 4.51e-20: 85: 21.78
+	Hs
		416603 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		S10A6_HUMAN (2-92): 4.58e-23: 86.5: 23.40
+	Hs
		396713 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		S10A8_HUMAN (2-94): 6.39e-23: 86.1: 22.92