HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18385518
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 803
+	Hs
		666186 SHC1_HUMAN (1-583): 0: 531: 100.00		VAV3_HUMAN (1-731): 3.11e-110: 358: 16.73
+	Hs
		209051 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		ARHG7_HUMAN (1-803): 0: 654: 100.00
+	Hs
		557687 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		ARHG7_HUMAN (1-803): 0: 654: 100.00
+	Mm
		1206687 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		ARHG7_MOUSE (1-797): 0: 570: 91.09
+	Hs
		924563 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		ARHG7_HUMAN (1-803): 0: 654: 100.00
+	Hs
		855787 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Hs
		209055 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48
+	Hs
		557698 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48
+	Hs
		69770 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		B1ALK7_HUMAN (180-797): 8.98e-163: 490: 99.35
+	Hs
		548628 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		548712 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		548645 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		655500 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		VAV3_HUMAN (1-731): 3.11e-110: 358: 16.73
+	Ce
		283752 CED6_CAEEL (123-481): 2.83e-45: 169: 15.10		VAV_CAEEL (2-676): 1.52e-78: 275: 16.64
+	Hs
		548677 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		855781 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Hs
		557763 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		ARHG2_HUMAN (62-801): 1.23e-80: 280: 13.33
+	Hs
		655405 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		FGD2_HUMAN (230-629): 5.88e-78: 266: 18.64
+	Mm
		1206702 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		ITSN1_MOUSE (21-252): 1.33e-10: 67.4: 17.00
+	Hs
		655386 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68