Protein: PPAC
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)

Gene: PPAC, ACP1
Organism: Homo sapiens
Interactions: 98
UniProt ID: P24666

Gene Ontology (top 5):
GO:0003993 - acid phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666068

PPAC
Low molecular weight phosphotyrosine protein phosphatase

2

1

High-throughput

0.754

High

666086

ACTB
Actin, cytoplasmic 1

2

2

High-throughput

0.628

High

666105

ACTBL
Beta-actin-like protein 2

2

2

High-throughput

0.628

High

666108

POTEE
POTE ankyrin domain family member E

2

1

High-throughput

0.628

High

666100

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.618

High

666111

TXND5
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.618

High

240781

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

410629

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

5

High-throughput

0.576

High

666083

EPHB1
Ephrin type-B receptor 1

1

3

Small-scale

0.561

High

666085

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

0

Small-scale

0.559

High

619499

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

666095

TNK1
Non-receptor tyrosine-protein kinase TNK1

1

4

High-throughput

0.536

High

666106

FBP1L
Formin-binding protein 1-like

1

0

High-throughput

0.518

High

666101

TESK1
Dual specificity testis-specific protein kinase 1

1

0

High-throughput

0.513

High

666114

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

666123

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.513

High

666128

PRD11
PR domain-containing protein 11

1

0

High-throughput

0.513

High

666071

EPHA2
Ephrin type-A receptor 2

1

3

Small-scale

0.512

High

666117

OPTN
Optineurin

1

0

High-throughput

0.493

High

362789

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

439644

INSR
Insulin receptor

1

4

Small-scale

0.479

High

666070

DUS1
Dual specificity protein phosphatase 1

1

1

High-throughput

0.479

High

666072

EPHB2
Ephrin type-B receptor 2

1

3

Small-scale

0.479

High

666078

ZAP70
Tyrosine-protein kinase ZAP-70

1

5

Small-scale

0.479

High

666089

DUSP2
Dual specificity protein phosphatase 2

1

1

High-throughput

0.479

High

666093

DNJC3
DnaJ homolog subfamily C member 3

1

2

High-throughput

0.479

High

666103

DUS28
Dual specificity phosphatase 28

1

3

High-throughput

0.479

High

666109

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

666110

DNJB7
DnaJ homolog subfamily B member 7

1

1

High-throughput

0.479

High

666115

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

1

High-throughput

0.479

High

666137

DUS12
Dual specificity protein phosphatase 12

1

3

High-throughput

0.479

High

666121

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.460

High

129999

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.458

High

227375

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

273489

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.458

High

293217

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

319408

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

339135

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.458

High

389038

FINC
Fibronectin

1

0

High-throughput

0.458

High

403831

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

538876

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

565154

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

646762

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

666069

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

666073

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

666074

METK2
S-adenosylmethionine synthase isoform type-2

1

0

High-throughput

0.458

High

666076

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

666077

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

666079

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

666081

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

666082

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

666084

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

666088

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

666090

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

666091

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.458

High

666092

PAK2
Serine/threonine-protein kinase PAK 2

1

0

High-throughput

0.458

High

666096

CUL3
Cullin-3

1

0

High-throughput

0.458

High

666097

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

666098

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

666099

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

666102

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

666107

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

666112

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

666118

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

666119

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

666120

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

666122

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

666126

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

666127

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

666129

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

666131

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

666133

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

666134

TES
Testin

1

0

High-throughput

0.458

High

666136

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.458

High

529105

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

563217

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

666080

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.426

High

666087

RHOA
Transforming protein RhoA

1

0

High-throughput

0.426

High

666104

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

666138

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

666125

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.282

High

666135

SMBT1
Scm-like with four MBT domains protein 1

1

0

High-throughput

0.282

High

484385

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

666124

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

666075

VGFR2
Vascular endothelial growth factor receptor 2

1

0

Small-scale

0.251

Low

212832

ZBT43
Zinc finger and BTB domain-containing protein 43

1

0

High-throughput

0.249

Low

217846

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

254524

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

259455

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

371188

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

652701

AAAD
Arylacetamide deacetylase

1

0

High-throughput

0.249

Low

666094

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

666113

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.249

Low

666116

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

666130

DJC27
DnaJ homolog subfamily C member 27

1

0

High-throughput

0.249

Low

666132

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.249

Low

666139

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025