HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: SOS2 (Q07890)
Son of sevenless homolog 2 (SOS-2)
Gene: SOS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	10675333, 19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 1332
+	Hs
		666085 SHC1_HUMAN (1-583): 0: 531: 100.00		SOS1_HUMAN (1-1330): 0: 913: 67.29
+	Mm
		957237 SHC1_MOUSE (1-583): 0: 527: 94.51		SOS1_MOUSE (1-1330): 0: 905: 67.34
+	Rn
		88906 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		D4A3T0_RAT (1-1330): 0: 910: 67.19
+	Hs
		557669 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SOS2_HUMAN (1-1332): 0: 962: 100.00
+	Hs
		655333 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SOS2_HUMAN (1-1332): 0: 962: 100.00
+	Hs
		209038 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		SOS1_HUMAN (1-1330): 0: 913: 67.29
+	Hs
		442816 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		SOS1_HUMAN (1-1330): 0: 913: 67.29
+	Hs
		557668 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		SOS1_HUMAN (1-1330): 0: 913: 67.29
+	Hs
		655332 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		SOS1_HUMAN (1-1330): 0: 913: 67.29
+	Hs
		666106 SHC1_HUMAN (1-583): 0: 531: 100.00		RPGF1_HUMAN (571-1020): 8.77e-96: 334: 25.99
+	Dm
		644374 SRC42_DROME (351-579): 6.25e-40: 154: 18.07		SOS_DROME (8-1329): 0: 708: 42.50
+	Hs
		442826 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		RPGF1_HUMAN (571-1020): 8.77e-96: 334: 25.99
+	Hs
		548628 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		VAV_HUMAN (51-665): 1.7e-84: 297: 13.44
+	Hs
		557763 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		ARHG2_HUMAN (30-849): 9.08e-97: 335: 11.63
+	Hs
		557683 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RPGF1_HUMAN (571-1020): 8.77e-96: 334: 25.99
+	Hs
		655361 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		RPGF1_HUMAN (571-1020): 8.77e-96: 334: 25.99
+	Hs
		548712 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		VAV_HUMAN (51-665): 1.7e-84: 297: 13.44
+	Hs
		548645 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		VAV_HUMAN (51-665): 1.7e-84: 297: 13.44
+	Hs
		557756 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RPGF5_HUMAN (610-1017): 6.86e-80: 276: 18.12
+	Hs
		557709 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RGPS1_HUMAN (772-936): 3.57e-19: 95.1: 30.41