HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7907978
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007173 - epidermal growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 532
+	Hs
		666186 SHC1_HUMAN (1-583): 0: 531: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		580939 SHC1_HUMAN (1-583): 0: 531: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		412038 SHC1_HUMAN (1-583): 0: 531: 100.00		FYN_HUMAN (357-529): 5.57e-50: 182: 20.88
+	Hs
		433604 SHC1_HUMAN (1-583): 0: 531: 100.00		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		433266 SHC1_HUMAN (1-583): 0: 531: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		522805 SHC1_HUMAN (1-583): 0: 531: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Mm
		403430 SHC1_MOUSE (1-583): 0: 527: 94.51		SRC_MOUSE (351-528): 1.55e-46: 172: 24.32
+	Hs
		666029 SHC1_HUMAN (1-583): 0: 531: 100.00		CSK_HUMAN (394-525): 1.94e-28: 119: 28.78
+	Hs
		855787 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		VAV2_HUMAN (81-526): 4.93e-78: 264: 14.77
+	Hs
		666035 SHC1_HUMAN (1-583): 0: 531: 100.00		KSYK_HUMAN (412-531): 6.62e-17: 86: 30.00
+	Mm
		815728 SHC1_MOUSE (1-583): 0: 527: 94.51		KSYK_MOUSE (412-531): 9.61e-16: 82.2: 28.33
+	Hs
		666104 SHC1_HUMAN (1-583): 0: 531: 100.00		GRAP_HUMAN (395-513): 1.95e-14: 74.4: 25.21
+	Hs
		666057 SHC1_HUMAN (1-583): 0: 531: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Mm
		957235 SHC1_MOUSE (1-583): 0: 527: 94.51		GRB2_MOUSE (427-513): 2.66e-13: 71: 29.89
+	Mm
		403451 SHC2_MOUSE (43-582): 6.38e-127: 386: 45.91		SRC_MOUSE (351-528): 1.55e-46: 172: 24.32
+	Mm
		403440 SHC3_MOUSE (128-582): 1.14e-111: 343: 53.26		SRC_MOUSE (351-528): 1.55e-46: 172: 24.32
+	Rn
		924995 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		GRB2_RAT (427-513): 2.66e-13: 71: 29.89
+	Hs
		924646 SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Hs
		924476 SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Hs
		442828 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		HCK_HUMAN (349-527): 4.62e-45: 168: 19.37