HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	24728074, 9804835, 14982882
Identification Methods	pull down, affinity chromatography technology, far western blotting, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005829 - cytosol GO:0007173 - epidermal growth factor receptor signaling pathway GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 694
+	Mm
		957247 SHC1_MOUSE (1-583): 0: 527: 94.51		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		666193 SHC1_HUMAN (1-583): 0: 531: 100.00		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		957250 SHC1_MOUSE (1-583): 0: 527: 94.51		GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33
+	Mm
		957233 SHC1_MOUSE (1-583): 0: 527: 94.51		Q3ZB59_MOUSE (3-691): 1.2e-140: 428: 38.33
+	Hs
		1035394 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		548703 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		1035413 VAV3_HUMAN (190-579): 2.86e-47: 179: 14.52		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		209049 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		855792 VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		442825 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		557681 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		275569 BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		655356 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		643113 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		557834 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		655510 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		643089 P85A_MOUSE (300-581): 6.66e-38: 151: 15.99		Q3ZB59_MOUSE (3-691): 1.2e-140: 428: 38.33
+	Dm
		1358412 Q9V3C8_DROME (128-581): 3.26e-84: 270: 36.56		DOS_DROME (7-655): 6.26e-82: 279: 18.50
+	Hs
		1153427 GULP1_HUMAN (137-418): 7.16e-48: 171: 19.79		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		1268502 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		DEFI6_HUMAN (4-111): 7.29e-15: 80.2: 21.30