HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.563

Property	Details
Experiments	10822173, 22974441
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043410 - positive regulation of MAPK cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 481
+	Rn
		1118081 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		DOK1_RAT (1-481): 0: 559: 83.99
+	Rn
		250473 SHC3_RAT (6-582): 2.29e-130: 396: 46.76		DOK1_RAT (1-481): 0: 559: 83.99
+	Hs
		235049 SHC1_HUMAN (1-583): 0: 531: 100.00		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		151717 SHC1_HUMAN (1-583): 0: 531: 100.00		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Mm
		724592 SHC1_MOUSE (1-583): 0: 527: 94.51		IRS1_MOUSE (6-373): 1.1e-77: 265: 17.27
+	Hs
		548746 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		1184732 SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		209149 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Hs
		442876 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		223011 NCK2_MOUSE (363-579): 1.02e-42: 159: 18.83		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		956524 NCK1_MOUSE (360-575): 1.9e-41: 155: 18.30		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Rn
		292432 GRB14_RAT (66-579): 8.12e-91: 291: 15.01		IRS1_RAT (6-373): 3.69e-78: 267: 17.27
+	Hs
		1115801 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		1184733 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		DOK3_HUMAN (1-458): 6.22e-116: 351: 31.21
+	Hs
		208960 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Mm
		223005 NCK2_MOUSE (363-579): 1.02e-42: 159: 18.83		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Mm
		250957 NCK1_MOUSE (360-575): 1.9e-41: 155: 18.30		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		207315 GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Hs
		208999 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Hs
		207290 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		FRS3_HUMAN (153-432): 4e-52: 185: 20.42