Interactor 1: IL12A (P29459)
Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)
Gene: IL12A

Interactor 2: IL12B (P29460)
Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40) (NK cell stimulatory factor chain 2) (NKSF2)
Gene: IL12B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.895

The method score is based on:

Property Details
Experiments 10899108, 10779781, 7527811, 8943050
Identification Methods x-ray crystallography, coimmunoprecipitation, comigration in non denaturing gel electrophoresis, competition binding
Interaction Type association, physical association, disulfide bond, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IL12~IL12p40_C
Common GO terms GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002860 - positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0005125 - cytokine activity
GO:0005143 - interleukin-12 receptor binding
GO:0005576 - extracellular region
and 21 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 219
Hs

1 328
+ Hs
+ Hs
+ Mm

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Last updated: 15 Jul 2024