Protein: SLT2
Mitogen-activated protein kinase SLT2/MPK1 (MAP kinase MPK1) (EC 2.7.11.24)

Gene: SLT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 243
UniProt ID: Q00772

Gene Ontology (top 5):
GO:0000196 - cell integrity MAPK cascade
GO:0000425 - pexophagy
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738041

MKK1
MAP kinase kinase MKK1/SSP32

10

20

Small-scale

0.977

High

800438

MSG5
Tyrosine-protein phosphatase MSG5

8

20

Small-scale

0.976

High

738071

MKK2
MAP kinase kinase MKK2/SSP33

7

20

Small-scale

0.970

High

825196

SDP1
Dual-specificity protein phosphatase SDP1

6

20

Small-scale

0.957

High

393181

HSP82
ATP-dependent molecular chaperone HSP82

6

20

Small-scale

0.949

High

1027257

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

5

20

Small-scale

0.929

High

671548

SWI4
Regulatory protein SWI4

3

6

Small-scale

0.891

High

488988

SWI6
Regulatory protein SWI6

2

8

Small-scale

0.825

High

817518

PTP3
Tyrosine-protein phosphatase 3

2

20

Small-scale

0.825

High

560752

KIN2
Serine/threonine-protein kinase KIN2

2

3

High-throughput

0.811

High

801982

KIC1
Serine/threonine-protein kinase KIC1

2

20

High-throughput

0.811

High

921480

SSK2
MAP kinase kinase kinase SSK2

2

20

High-throughput

0.793

High

671021

SIS1
Protein SIS1

2

10

High-throughput

0.789

High

1027281

SKG3
Protein SKG3

2

0

High-throughput

0.770

High

364693

CDK1
Cyclin-dependent kinase 1

2

17

Small-scale

0.767

High

1027256

SLT2
Mitogen-activated protein kinase SLT2/MPK1

2

18

Small-scale

0.754

High

867858

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

6

Small-scale

0.747

High

1027298

RLM1
Transcription factor RLM1

6

15

Small-scale

0.733

High

736128

ARP2
Actin-related protein 2

1

9

High-throughput

0.691

High

835986

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

19

High-throughput

0.691

High

873802

DSK2
Ubiquitin domain-containing protein DSK2

1

5

High-throughput

0.691

High

1027310

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

10

High-throughput

0.691

High

402084

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

4

Small-scale

0.667

High

793366

PP2C4
Protein phosphatase 2C homolog 4

1

12

Small-scale

0.647

High

801896

KSP1
Serine/threonine-protein kinase KSP1

1

20

High-throughput

0.647

High

815942

PP2C2
Protein phosphatase 2C homolog 2

1

13

Small-scale

0.647

High

1027268

STE20
Serine/threonine-protein kinase STE20

1

9

Small-scale

0.647

High

1027277

AVO2
Target of rapamycin complex 2 subunit AVO2

1

4

Small-scale

0.647

High

671686

SCJ1
DnaJ-related protein SCJ1

1

11

High-throughput

0.646

High

676264

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.646

High

763481

MDJ1
DnaJ homolog 1, mitochondrial

1

13

High-throughput

0.646

High

948625

ACT
Actin

1

8

High-throughput

0.646

High

712762

PTP2
Tyrosine-protein phosphatase 2

2

20

Small-scale

0.639

High

654740

SPA2
Protein SPA2

3

9

Small-scale

0.637

High

437948

KAPC
cAMP-dependent protein kinase type 3

1

20

High-throughput

0.621

High

441221

KAPA
cAMP-dependent protein kinase type 1

1

20

High-throughput

0.621

High

550598

SST2
Protein SST2

1

2

High-throughput

0.621

High

667110

CG22
G2/mitotic-specific cyclin-2

1

4

High-throughput

0.621

High

748625

STE5
Protein STE5

1

2

High-throughput

0.621

High

752009

PACC
pH-response transcription factor pacC/RIM101

1

9

High-throughput

0.621

High

792435

BOI1
BEM1-interacting protein 1

1

9

High-throughput

0.621

High

810659

SSN3
Meiotic mRNA stability protein kinase SSN3

1

19

High-throughput

0.621

High

924679

TEP1
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1

1

3

High-throughput

0.621

High

925342

CRZ1
Transcriptional regulator CRZ1

1

2

High-throughput

0.621

High

1027280

FAR10
Factor arrest protein 10

1

1

High-throughput

0.621

High

1027306

ARP6
Actin-like protein ARP6

1

9

High-throughput

0.621

High

1027307

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

11

High-throughput

0.621

High

444868

SIR3
Regulatory protein SIR3

2

2

Small-scale

0.619

High

908513

ROM2
RHO1 GDP-GTP exchange protein 2

2

9

Small-scale

0.619

High

464630

PBS2
MAP kinase kinase PBS2

1

20

Small-scale

0.618

High

645968

DBF2
Cell cycle protein kinase DBF2

1

13

High-throughput

0.618

High

694160

CDC15
Cell division control protein 15

1

20

High-throughput

0.618

High

734319

DBF20
Serine/threonine-protein kinase DBF20

1

14

High-throughput

0.618

High

737926

HOG1
Mitogen-activated protein kinase HOG1

1

18

Small-scale

0.618

High

1026798

CDC14
Tyrosine-protein phosphatase CDC14

1

20

High-throughput

0.618

High

740278

SMI1
Cell wall assembly regulator SMI1

2

0

Small-scale

0.615

High

1027295

RCN2
Regulator of calcineurin 2

2

0

Small-scale

0.602

High

823442

MPM1
Mitochondrial peculiar membrane protein 1

2

0

High-throughput

0.592

High

746749

KPR1
Ribose-phosphate pyrophosphokinase 1

2

9

Small-scale

0.586

High

798613

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.573

High

742187

HSP7F
Heat shock protein homolog SSE1

2

20

Small-scale

0.571

High

668437

PTP1
Tyrosine-protein phosphatase 1

1

15

Small-scale

0.561

High

677696

MRC1
Mediator of replication checkpoint protein 1

1

1

Small-scale

0.561

High

801184

SIC1
Protein SIC1

1

1

Small-scale

0.561

High

564669

STE12
Protein STE12

1

4

High-throughput

0.554

High

808537

TEM1
Protein TEM1

1

3

High-throughput

0.553

High

711519

BEM1
Bud emergence protein 1

1

5

High-throughput

0.552

High

744229

GLRX4
Monothiol glutaredoxin-4

1

7

Small-scale

0.552

High

1027271

GLRX3
Monothiol glutaredoxin-3

1

7

Small-scale

0.552

High

558834

CAF20
Cap-associated protein CAF20

1

1

Small-scale

0.536

High

420975

PMA1
Plasma membrane ATPase 1

1

6

High-throughput

0.536

High

453304

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.536

High

470015

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

470037

GAL7
Galactose-1-phosphate uridylyltransferase

1

1

High-throughput

0.536

High

518367

IF4A
ATP-dependent RNA helicase eIF4A

1

11

High-throughput

0.536

High

684535

PDC6
Pyruvate decarboxylase isozyme 3

1

3

High-throughput

0.536

High

705786

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

4

High-throughput

0.536

High

750884

PRS6B
26S proteasome regulatory subunit 6B homolog

1

5

High-throughput

0.536

High

779566

LHS1
Heat shock protein 70 homolog LHS1

1

19

High-throughput

0.536

High

792189

GBLP
Small ribosomal subunit protein RACK1

1

15

High-throughput

0.536

High

802966

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.536

High

806489

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

High-throughput

0.536

High

825469

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

6

High-throughput

0.536

High

828310

MKT1
Post-transcriptional regulator MKT1

1

1

High-throughput

0.536

High

916795

ROM1
RHO1 GDP-GTP exchange protein 1

1

10

High-throughput

0.536

High

922678

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

3

High-throughput

0.536

High

1027264

DIG1
Down-regulator of invasive growth 1

1

3

High-throughput

0.536

High

1027270

OYE2
NADPH dehydrogenase 2

1

1

High-throughput

0.536

High

1027293

SOG2
Leucine-rich repeat-containing protein SOG2

1

6

High-throughput

0.536

High

916880

RTF1
RNA polymerase-associated protein RTF1

1

1

Small-scale

0.529

High

1018314

CTR9
RNA polymerase-associated protein CTR9

1

1

Small-scale

0.529

High

1027260

ADA2
SAGA complex subunit ADA2

1

5

Small-scale

0.529

High

1027287

CYK3
Cytokinesis protein 3

1

0

Small-scale

0.518

High

924937

NST1
Stress response protein NST1

1

8

Small-scale

0.515

High

1027282

GGA1
ADP-ribosylation factor-binding protein GGA1

1

0

Small-scale

0.513

High

366831

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.513

High

439158

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.513

High

631984

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

751462

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.513

High

904465

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

918653

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.513

High

1027267

EBS1
Nonsense-mediated mRNA decay factor EBS1

1

0

High-throughput

0.513

High

1027292

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

1027304

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

800267

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.506

High

1027285

CDC73
Cell division control protein 73

1

0

Small-scale

0.506

High

1027265

GCN5
Histone acetyltransferase GCN5

1

9

Small-scale

0.506

High

817750

TSC11
Target of rapamycin complex 2 subunit TSC11

1

2

Small-scale

0.501

High

850616

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

3

High-throughput

0.501

High

367100

ATPB
ATP synthase subunit beta, mitochondrial

1

12

High-throughput

0.500

High

367394

CISY1
Citrate synthase, mitochondrial

1

2

High-throughput

0.500

High

368731

PMG1
Phosphoglycerate mutase 1

1

3

High-throughput

0.500

High

405129

LEU3
3-isopropylmalate dehydrogenase

1

6

High-throughput

0.500

High

408340

GAL1
Galactokinase

1

1

High-throughput

0.500

High

416470

HXKA
Hexokinase-1

1

3

High-throughput

0.500

High

452954

ATPA
ATP synthase subunit alpha, mitochondrial

1

12

High-throughput

0.500

High

453744

PYR1
Multifunctional protein URA2

1

10

High-throughput

0.500

High

531382

METK1
S-adenosylmethionine synthase 1

1

6

High-throughput

0.500

High

555132

G6PI
Glucose-6-phosphate isomerase

1

3

High-throughput

0.500

High

590700

HSP26
Heat shock protein 26

1

8

High-throughput

0.500

High

599060

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

12

High-throughput

0.500

High

607781

HXKG
Glucokinase-1

1

3

High-throughput

0.500

High

619378

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.500

High

621396

METK2
S-adenosylmethionine synthase 2

1

6

High-throughput

0.500

High

644825

CLH
Clathrin heavy chain

1

3

High-throughput

0.500

High

661679

MPCP
Mitochondrial phosphate carrier protein

1

13

High-throughput

0.500

High

673524

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

7

High-throughput

0.500

High

679972

CDC48
Cell division control protein 48

1

6

High-throughput

0.500

High

836846

MPG1
Mannose-1-phosphate guanyltransferase

1

4

High-throughput

0.500

High

1027258

PRS8
26S proteasome regulatory subunit 8 homolog

1

7

High-throughput

0.500

High

1027290

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

1027300

HSP42
Heat shock protein 42

1

8

High-throughput

0.500

High

1027302

RPN6
26S proteasome regulatory subunit RPN6

1

2

High-throughput

0.489

High

548232

BIK1
Nuclear fusion protein BIK1

1

2

High-throughput

0.481

High

548292

FUS1
Nuclear fusion protein FUS1

1

2

High-throughput

0.481

High

639569

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

1

High-throughput

0.481

High

672025

MSH3
DNA mismatch repair protein MSH3

1

2

High-throughput

0.481

High

673061

SED4
Putative guanine nucleotide-exchange factor SED4

1

3

High-throughput

0.481

High

682934

MSH2
DNA mismatch repair protein MSH2

1

2

High-throughput

0.481

High

698118

PEP3
Vacuolar membrane protein PEP3

1

1

High-throughput

0.481

High

721693

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.481

High

745170

CACP
Carnitine O-acetyltransferase, mitochondrial

1

1

High-throughput

0.481

High

750200

UFD4
Ubiquitin fusion degradation protein 4

1

4

High-throughput

0.481

High

779873

MID2
Cell wall integrity sensor MID2

1

1

High-throughput

0.481

High

780629

CAB3
Coenzyme A biosynthesis protein 3

1

1

High-throughput

0.481

High

790587

VRP1
Verprolin

1

7

High-throughput

0.481

High

792601

KPR4
Ribose-phosphate pyrophosphokinase 4

1

9

Small-scale

0.481

High

793891

PCH2
Pachytene checkpoint protein 2

1

11

High-throughput

0.481

High

794145

ERT1
Transcription activator of gluconeogenesis ERT1

1

1

High-throughput

0.481

High

800672

KPR2
Ribose-phosphate pyrophosphokinase 2

1

9

Small-scale

0.481

High

800856

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.481

High

801791

KPR3
Ribose-phosphate pyrophosphokinase 3

1

9

Small-scale

0.481

High

824616

VTH1
VPS10 homolog 1

1

1

High-throughput

0.481

High

824665

BNR1
BNI1-related protein 1

1

1

High-throughput

0.481

High

826394

MPH1
ATP-dependent DNA helicase MPH1

1

7

High-throughput

0.481

High

829868

RTS2
Zinc finger protein RTS2

1

1

High-throughput

0.481

High

850631

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.481

High

863399

RSF2
Respiration factor 2

1

3

High-throughput

0.481

High

865278

LSM8
LSM2-LSM8 complex subunit LSM8

1

2

High-throughput

0.481

High

1027259

SKO1
CRE-binding bZIP protein SKO1

1

1

High-throughput

0.481

High

1027262

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

3

High-throughput

0.481

High

1027275

GRH1
GRASP65 homolog protein 1

1

5

High-throughput

0.481

High

1027283

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

9

High-throughput

0.481

High

1027286

SSK1
Osmolarity two-component system protein SSK1

1

2

High-throughput

0.481

High

1027289

YAP7
AP-1-like transcription factor YAP7

1

1

High-throughput

0.481

High

1027296

ULA1
NEDD8-activating enzyme E1 regulatory subunit

1

2

High-throughput

0.481

High

738899

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

Small-scale

0.480

High

864033

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.480

High

594985

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

0

High-throughput

0.479

High

461000

LTE1
Guanine nucleotide exchange factor LTE1

1

4

High-throughput

0.479

High

536156

ARF1
ADP-ribosylation factor 1

1

3

High-throughput

0.479

High

594514

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.479

High

645635

AFT1
Iron-regulated transcriptional activator AFT1

1

1

Small-scale

0.479

High

663323

FPS1
Glycerol uptake/efflux facilitator protein

1

1

Small-scale

0.479

High

825297

MOB1
DBF2 kinase activator protein MOB1

1

2

High-throughput

0.479

High

850151

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.479

High

923965

BNI4
Protein BNI4

1

1

Small-scale

0.479

High

454348

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.460

High

649553

CHL1
ATP-dependent DNA helicase CHL1

1

0

High-throughput

0.460

High

664335

SSD1
Protein SSD1

1

0

High-throughput

0.460

High

666225

MNE1
Protein MNE1

1

0

High-throughput

0.460

High

734843

COX24
Small ribosomal subunit protein mS38

1

0

High-throughput

0.460

High

735401

MCM10
Minichromosome maintenance protein 10

1

0

High-throughput

0.460

High

744804

ALK2
Serine/threonine-protein kinase Haspin homolog ALK2

1

0

High-throughput

0.460

High

746073

SEC6
Exocyst complex component SEC6

1

0

High-throughput

0.460

High

750050

PDR3
Transcription factor PDR3

1

0

High-throughput

0.460

High

778877

FOLC
Probable folylpolyglutamate synthase

1

0

High-throughput

0.460

High

780664

SRX1
Sulfiredoxin

1

0

High-throughput

0.460

High

794793

SFT2
Protein transport protein SFT2

1

0

High-throughput

0.460

High

796820

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.460

High

797498

UBS1
Ubiquitin-conjugating enzyme suppressor 1

1

0

High-throughput

0.460

High

797938

YBP1
YAP1-binding protein 1

1

0

High-throughput

0.460

High

798196

DPH7
Diphthine methyltransferase

1

0

High-throughput

0.460

High

804056

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.460

High

804865

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

High-throughput

0.460

High

805835

WSS1
DNA-dependent metalloprotease WSS1

1

0

High-throughput

0.460

High

806698

AIM46
Altered inheritance of mitochondria protein 46, mitochondrial

1

0

High-throughput

0.460

High

813741

PEX22
Peroxisome assembly protein 22

1

0

High-throughput

0.460

High

825947

SYG1
Protein SYG1

1

0

High-throughput

0.460

High

826312

URM1
Ubiquitin-related modifier 1

1

0

High-throughput

0.460

High

843241

STB1
Protein STB1

1

0

High-throughput

0.460

High

849701

FMP32
Protein FMP32, mitochondrial

1

0

High-throughput

0.460

High

863067

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.460

High

918065

PIB2
Glutamine sensor PIB2

1

0

High-throughput

0.460

High

918540

LST7
Protein LST7

1

0

High-throughput

0.460

High

1027263

INA17
Inner membrane assembly complex subunit 17

1

0

High-throughput

0.460

High

1027266

CWC21
Pre-mRNA-splicing factor CWC21

1

0

High-throughput

0.460

High

1027269

GOT1
Protein transport protein GOT1

1

0

High-throughput

0.460

High

1027272

LIC4
Protein ATC1/LIC4

1

0

High-throughput

0.460

High

1027273

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.460

High

1027276

RBA50
RNA polymerase II-associated protein RBA50

1

0

High-throughput

0.460

High

1027279

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

0

High-throughput

0.460

High

1027284

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.460

High

1027294

GRE1
Protein GRE1

1

0

High-throughput

0.460

High

1027297

TIP41
Type 2A phosphatase activator TIP41

1

0

High-throughput

0.460

High

1027299

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

1027301

SCM3
Protein SCM3

1

0

High-throughput

0.460

High

1027305

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.460

High

1027308

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.460

High

1027309

SRN2
Protein SRN2

1

0

High-throughput

0.460

High

575362

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

Small-scale

0.458

High

796789

FES1
Hsp70 nucleotide exchange factor FES1

1

0

Small-scale

0.458

High

1027303

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.458

High

743802

TCA17
TRAPP-associated protein TCA17

1

1

High-throughput

0.457

High

524861

HSP71
Heat shock protein SSA1

1

17

High-throughput

0.445

High

545920

SSB1
Ribosome-associated molecular chaperone SSB1

1

19

High-throughput

0.445

High

819518

SSB2
Ribosome-associated molecular chaperone SSB2

1

19

High-throughput

0.445

High

583752

DAL5
Allantoate permease

1

3

High-throughput

0.439

High

720862

ITR2
Myo-inositol transporter 2

1

4

High-throughput

0.439

High

803370

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

3

High-throughput

0.439

High

816973

BIM1
Protein BIM1

1

5

High-throughput

0.439

High

836169

OYE3
NADPH dehydrogenase 3

1

1

High-throughput

0.439

High

932779

HXT15
Hexose transporter HXT15

1

4

High-throughput

0.439

High

1027274

UTP15
U3 small nucleolar RNA-associated protein 15

1

5

High-throughput

0.439

High

1027278

NUP59
Nucleoporin ASM4

1

1

High-throughput

0.439

High

1027291

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

1

High-throughput

0.439

High

797982

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.438

High

917717

USE1
Protein transport protein USE1

1

0

High-throughput

0.261

Low

1027261

YP077
Uncharacterized protein YPL077C

1

0

High-throughput

0.261

Low

798539

BIT2
Probable target of rapamycin complex 2 subunit BIT2

1

0

High-throughput

0.251

Low

850533

PTR3
SPS-sensor component PTR3

1

0

High-throughput

0.251

Low

1027288

PAU23
Seripauperin-23

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025