HitPredict

Interactor 1: IL12A (P29459)
Interleukin-12 subunit alpha (IL-12A) (Cytotoxic lymphocyte maturation factor 35 kDa subunit) (CLMF p35) (IL-12 subunit p35) (NK cell stimulatory factor chain 1) (NKSF1)
Gene: IL12A

Interactor 2: IRF8 (Q02556)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (H-ICSBP) (ICSBP)
Gene: IRF8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	19164128, 15489234, 18316378
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006955 - immune response GO:0032729 - positive regulation of type II interferon production
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 219 Hs			1 426
+	Hs
		667334 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IRF5_HUMAN (9-414): 5.23e-156: 451: 30.36
+	Hs
		667337 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IRF4_HUMAN (6-386): 9.59e-150: 434: 43.96
+	Hs
		667336 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IRF3_HUMAN (9-399): 1.44e-139: 407: 26.68
+	Hs
		667328 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IRF9_HUMAN (5-387): 8.71e-125: 368: 32.32
+	Hs
		667338 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IRF7_HUMAN (12-385): 3.06e-114: 345: 21.91
+	Hs
		501001 IL12A_HUMAN (1-219): 1.83e-123: 350: 100.00		IRF1_HUMAN (9-187): 2.59e-62: 206: 33.69
+	Mm
		547387 IL12A_MOUSE (1-219): 8.51e-115: 328: 58.90		IRF1_MOUSE (9-186): 1.4e-58: 196: 32.09