HitPredict

Interactor 1: SPTC1 (P25045)
Serine palmitoyltransferase 1 (SPT 1) (SPT1) (EC 2.3.1.50) (Long chain base biosynthesis protein 1)
Gene: LCB1

Interactor 2: SAC1 (P32368)
Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Recessive suppressor of secretory defect)
Gene: SAC1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.746

The method score is based on:

Property Details
Experiments 20182505, 30529276, 37982431, 39167489, 37794019, 37968396, 38285738, 23237950
Identification Methods anti tag coimmunoprecipitation, affinity chromatography technology, biochemical
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0017059 - serine palmitoyltransferase complex
GO:0090156 - intracellular sphingolipid homeostasis
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 558
Sc

1 623
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025