Protein: SAC1
Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Recessive suppressor of secretory defect)

Gene: SAC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 106
UniProt ID: P32368

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004438 - phosphatidylinositol-3-phosphate phosphatase activity
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

735869

VPS74
Vacuolar protein sorting-associated protein 74

2

1

Small-scale

0.841

High

668449

SPTC1
Serine palmitoyltransferase 1

8

1

Small-scale

0.746

High

735868

ORM2
Protein ORM2

4

1

Small-scale

0.683

High

735844

LCB2
Serine palmitoyltransferase 2

4

1

Small-scale

0.672

High

735853

ORM1
Protein ORM1

3

1

Small-scale

0.656

High

579029

HSC82
ATP-dependent molecular chaperone HSC82

3

3

High-throughput

0.633

High

735828

OSH3
Oxysterol-binding protein homolog 3

1

3

Small-scale

0.589

High

735823

IST2
Increased sodium tolerance protein 2

2

0

Small-scale

0.588

High

510293

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.571

High

735812

HSP78
Heat shock protein 78, mitochondrial

2

2

High-throughput

0.571

High

569388

DPM1
Dolichol-phosphate mannosyltransferase

2

0

Small-scale

0.569

High

735833

ATC3
Phospholipid-transporting ATPase DRS2

1

1

Small-scale

0.552

High

735874

TSC3
Serine palmitoyltransferase-regulating protein TSC3

2

0

Small-scale

0.547

High

672785

ELO2
Fatty acid elongase 2

1

1

High-throughput

0.541

High

735815

YET1
Endoplasmic reticulum transmembrane protein 1

1

1

High-throughput

0.541

High

735818

SRPB
Signal recognition particle receptor subunit beta

1

3

High-throughput

0.541

High

735824

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.541

High

735840

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.541

High

735873

YOP1
Protein YOP1

1

1

High-throughput

0.541

High

735817

CENPA
Histone H3-like centromeric protein CSE4

2

1

Small-scale

0.535

High

726831

HS104
Heat shock protein 104

2

2

High-throughput

0.533

High

735841

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.518

High

735851

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

735858

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.518

High

735816

KES1
Oxysterol-binding protein homolog 4

1

4

Small-scale

0.501

High

452643

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.493

High

657063

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.493

High

735859

INA17
Inner membrane assembly complex subunit 17

1

0

High-throughput

0.493

High

735861

USA1
U1 SNP1-associating protein 1

1

0

High-throughput

0.486

High

679476

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

726067

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

1

Small-scale

0.479

High

735811

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

2

Small-scale

0.479

High

735814

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

1

Small-scale

0.479

High

735829

OSH7
Oxysterol-binding protein homolog 7

1

4

Small-scale

0.479

High

735830

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

735838

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

3

Small-scale

0.479

High

735847

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

735848

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

2

Small-scale

0.479

High

735850

OST3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3

1

1

Small-scale

0.479

High

735855

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

735856

TMEDA
Endoplasmic reticulum vesicle protein 25

1

3

Small-scale

0.479

High

735860

TCB3
Tricalbin-3

1

2

Small-scale

0.479

High

735866

RTN1
Reticulon-like protein 1

1

3

Small-scale

0.479

High

735827

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.470

High

382856

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

427997

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

Small-scale

0.458

High

438643

SC160
Protein SCP160

1

0

High-throughput

0.458

High

577067

SEC63
Protein translocation protein SEC63

1

0

Small-scale

0.458

High

624725

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.458

High

636288

ACO1
Acyl-CoA desaturase 1

1

0

Small-scale

0.458

High

647042

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

715027

ERG9
Squalene synthase ERG9

1

0

Small-scale

0.458

High

735813

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

Small-scale

0.458

High

735819

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

735820

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

735826

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

Small-scale

0.458

High

735831

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

735835

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

735836

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

Small-scale

0.458

High

735845

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

735846

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

735852

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

735865

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

735870

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

0

Small-scale

0.458

High

526160

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

592088

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

626645

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

735837

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

735867

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

12

High-throughput

0.445

High

574860

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.438

High

392402

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.437

High

670455

SIS1
Protein SIS1

1

5

High-throughput

0.437

High

706476

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

709620

BMH1
Protein BMH1

1

2

High-throughput

0.437

High

735810

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.437

High

735834

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

735843

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.437

High

735863

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

394344

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

735825

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.426

High

481530

HSP73
Heat shock protein SSA3

1

8

High-throughput

0.407

High

523339

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.407

High

535991

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

1

High-throughput

0.407

High

544143

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.407

High

600999

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.407

High

675806

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.407

High

735839

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.407

High

735857

PMP3
Plasma membrane proteolipid 3

1

0

High-throughput

0.282

High

735822

IMB2
Importin subunit beta-2

1

0

High-throughput

0.279

Low

735832

STM1
Suppressor protein STM1

1

0

High-throughput

0.269

Low

735864

SAS4
Something about silencing protein 4

1

0

High-throughput

0.269

Low

735872

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.269

Low

735821

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

735849

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

Small-scale

0.249

Low

735854

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

735871

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.249

Low

735842

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.238

Low

381942

H4
Histone H4

1

0

High-throughput

0.232

Low

383277

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.232

Low

409703

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.232

Low

432519

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

531653

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.232

Low

569733

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

570225

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.232

Low

655414

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low

735862

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025