Protein: LCB2
Serine palmitoyltransferase 2 (SPT 2) (EC 2.3.1.50) (Long chain base biosynthesis protein 2)

Gene: LCB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 50
UniProt ID: P40970

Gene Ontology (top 5):
GO:0004758 - serine C-palmitoyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0016020 - membrane
GO:0017059 - serine palmitoyltransferase complex
GO:0030148 - sphingolipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

668456

SPTC1
Serine palmitoyltransferase 1

11

10

Small-scale

0.977

High

829998

ORM2
Protein ORM2

6

8

Small-scale

0.943

High

829994

ORM1
Protein ORM1

2

8

Small-scale

0.789

High

735844

SAC1
Phosphatidylinositol-3-phosphatase SAC1

4

1

Small-scale

0.672

High

829999

TSC3
Serine palmitoyltransferase-regulating protein TSC3

3

1

Small-scale

0.662

High

709817

BMH1
Protein BMH1

3

2

High-throughput

0.604

High

531343

METK1
S-adenosylmethionine synthase 1

2

1

High-throughput

0.567

High

621380

METK2
S-adenosylmethionine synthase 2

2

1

High-throughput

0.567

High

760283

BMH2
Protein BMH2

2

2

High-throughput

0.567

High

816589

GEA2
ARF guanine-nucleotide exchange factor 2

2

1

High-throughput

0.567

High

802641

YHI0
Putative proline--tRNA ligase YHR020W

2

1

High-throughput

0.537

High

763803

CSG2
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

1

0

High-throughput

0.518

High

486216

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.489

High

726095

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

1

High-throughput

0.479

High

751704

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

1

High-throughput

0.479

High

754696

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

1

High-throughput

0.479

High

822297

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.479

High

554354

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.458

High

577154

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.458

High

745352

EMP24
Endosomal protein P24B

1

0

High-throughput

0.458

High

816194

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

829993

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.458

High

453647

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

803581

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.445

High

579565

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

752369

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.437

High

812386

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

829995

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

829997

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.437

High

631946

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.426

High

386745

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

526927

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.407

High

592308

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

734126

EF2
Elongation factor 2

1

1

High-throughput

0.407

High

740178

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.407

High

804233

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.407

High

818993

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

829992

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

817882

IMB4
Importin subunit beta-4

3

0

High-throughput

0.335

High

661645

MPCP
Mitochondrial phosphate carrier protein

2

0

High-throughput

0.324

High

722018

XPO1
Exportin-1

2

0

High-throughput

0.324

High

796087

IMB2
Importin subunit beta-2

2

0

High-throughput

0.324

High

803137

ECM29
Proteasome component ECM29

2

0

High-throughput

0.324

High

575468

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

2

0

High-throughput

0.307

High

801062

FKS1
1,3-beta-glucan synthase component FKS1

2

0

High-throughput

0.307

High

825447

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

0

High-throughput

0.307

High

394650

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

427318

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

712593

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

829996

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025