HitPredict

Interactor 1: TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Gene: TYK2

Interactor 2: LRC46 (Q96FV0)
Leucine-rich repeat-containing protein 46
Gene: LRRC46

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_4~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1187 Hs			1 321
+	Hs
		669199 TYK2_HUMAN (1-1187): 0: 997: 100.00		LRC61_HUMAN (11-269): 1.07e-36: 134: 23.13
+	Hs
		411718 LCK_HUMAN (879-1183): 1.61e-95: 316: 31.09		SCRIB_HUMAN (1-224): 6.78e-32: 127: 15.29
+	Hs
		411898 LCK_HUMAN (879-1183): 1.61e-95: 316: 31.09		NISCH_HUMAN (62-291): 6.7e-29: 118: 24.08
+	Hs
		433876 LYN_HUMAN (890-1179): 2.84e-91: 305: 33.45		CEP97_HUMAN (6-233): 1.66e-32: 129: 19.74
+	Hs
		433758 LYN_HUMAN (890-1179): 2.84e-91: 305: 33.45		SCRIB_HUMAN (1-224): 6.78e-32: 127: 15.29
+	Hs
		434090 LYN_HUMAN (890-1179): 2.84e-91: 305: 33.45		NISCH_HUMAN (62-291): 6.7e-29: 118: 24.08
+	At
		1114696 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		ERECT_ARATH (2-246): 3.24e-31: 125: 18.46
+	At
		1278242 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		BRL1_ARATH (49-312): 4.07e-29: 119: 16.79
+	At
		287464 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		SKM1_ARATH (2-203): 6.8e-25: 107: 19.62
+	Hs
		412308 FYN_HUMAN (813-1182): 7.36e-96: 318: 26.54		LRIQ1_HUMAN (16-166): 6.44e-13: 71.4: 23.46
+	Hs
		561389 FER_HUMAN (816-1176): 2.54e-93: 320: 25.62		PP1R7_HUMAN (6-105): 3.8e-12: 68.1: 17.48
+	At
		1278223 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		IRK_ARATH (113-320): 2.44e-23: 102: 10.85
+	At
		1278216 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		BRL3_ARATH (93-320): 1.37e-20: 94.5: 14.62
+	At
		1167621 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		ERL2_ARATH (217-320): 6.16e-11: 65.3: 18.10
+	At
		99017 BAK1_ARATH (401-829): 3.97e-83: 285: 15.52		RGI4_ARATH (213-320): 5.68e-09: 59.5: 16.51
+	At
		1341095 BAME2_ARATH (88-590): 4.81e-37: 153: 12.07		CLV1_ARATH (48-312): 1.66e-33: 132: 13.77
+	At
		1114713 BAME2_ARATH (88-590): 4.81e-37: 153: 12.07		ERECT_ARATH (2-246): 3.24e-31: 125: 18.46
+	At
		1338257 BAME2_ARATH (88-590): 4.81e-37: 153: 12.07		BRL3_ARATH (93-320): 1.37e-20: 94.5: 14.62
+	At
		221776 GSO2_ARATH (107-597): 2.86e-38: 158: 8.53		BAME1_ARATH (197-311): 3.11e-09: 60.3: 12.07
+	Gm
		1341216 CLV1B_SOYBN (118-719): 7.5e-36: 149: 8.50		CLV1B_SOYBN (201-319): 7.21e-09: 59.1: 10.74