Protein: VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4)

Gene: VKORL, VKORC1L1
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q8N0U8

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0017187 - peptidyl-glutamic acid carboxylation
GO:0034599 - cellular response to oxidative stress
GO:0042373 - vitamin K metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884464

PCY1A
Choline-phosphate cytidylyltransferase A

4

1

High-throughput

0.689

High

1322224

PCY1B
Choline-phosphate cytidylyltransferase B

3

1

High-throughput

0.665

High

1322221

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

2

High-throughput

0.606

High

1322202

PGAP3
GPI-specific phospholipase A2-like PGAP3

2

0

High-throughput

0.585

High

1322192

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

1322195

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.580

High

1197823

S39AC
Zinc transporter ZIP12

2

1

High-throughput

0.574

High

967319

TSN5
Tetraspanin-5

2

6

High-throughput

0.558

High

1322222

GPR52
G-protein coupled receptor 52

2

2

High-throughput

0.558

High

1214409

GORAB
RAB6-interacting golgin

2

1

High-throughput

0.553

High

1322204

TMM80
Transmembrane protein 80

2

1

High-throughput

0.553

High

835325

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

2

High-throughput

0.549

High

1322193

SPP2B
Signal peptide peptidase-like 2B

2

1

High-throughput

0.549

High

1322194

SPP
Signal peptide peptidase

1

1

High-throughput

0.536

High

336551

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

701413

5HT1B
5-hydroxytryptamine receptor 1B

1

0

High-throughput

0.513

High

845075

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

1322216

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.513

High

822750

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

125032

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.489

High

141845

ACKR2
Atypical chemokine receptor 2

1

3

High-throughput

0.489

High

165987

FFAR1
Free fatty acid receptor 1

1

6

High-throughput

0.489

High

252612

TSN2
Tetraspanin-2

1

6

High-throughput

0.489

High

320468

TM63A
Mechanosensitive cation channel TMEM63A

1

1

High-throughput

0.489

High

349478

TSN15
Tetraspanin-15

1

5

High-throughput

0.489

High

640416

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

5

High-throughput

0.489

High

669024

FPR2
N-formyl peptide receptor 2

1

8

High-throughput

0.489

High

669232

NK1R
Substance-P receptor

1

1

High-throughput

0.489

High

709270

AA2BR
Adenosine receptor A2b

1

1

High-throughput

0.489

High

733018

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

2

High-throughput

0.489

High

833836

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.489

High

868303

P2RY1
P2Y purinoceptor 1

1

5

High-throughput

0.489

High

878052

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.489

High

956936

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.489

High

1242855

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.489

High

1288402

TSN33
Tetraspanin-33

1

5

High-throughput

0.489

High

1291839

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

6

High-throughput

0.489

High

1310215

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

1322208

CML1
Chemerin-like receptor 1

1

6

High-throughput

0.489

High

1322214

AT133
Polyamine-transporting ATPase 13A3

1

1

High-throughput

0.489

High

1322217

GP173
Probable G-protein coupled receptor 173

1

1

High-throughput

0.489

High

1322223

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

3

High-throughput

0.489

High

374044

RASN
GTPase NRas

1

1

High-throughput

0.479

High

375707

RASK
GTPase KRas

1

1

High-throughput

0.479

High

669195

EDNRA
Endothelin-1 receptor

1

2

High-throughput

0.479

High

904002

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

1249007

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1322200

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

2

High-throughput

0.479

High

1322210

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

1

Small-scale

0.479

High

369551

ANGT
Angiotensinogen

1

1

High-throughput

0.470

High

398006

KLKB1
Plasma kallikrein

1

2

High-throughput

0.470

High

173987

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

417569

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418258

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

847595

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

951256

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1200245

T4S20
Transmembrane 4 L6 family member 20

1

0

High-throughput

0.458

High

1322197

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

1322201

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1322207

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1322212

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

218445

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

720681

AGTR1
Type-1 angiotensin II receptor

1

5

High-throughput

0.437

High

901380

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.437

High

1238732

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1322191

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1322199

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1322203

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1322211

P2Y12
P2Y purinoceptor 12

1

5

High-throughput

0.437

High

1322219

TM216
Transmembrane protein 216

1

1

High-throughput

0.437

High

1322225

FADS3
Fatty acid desaturase 3

1

0

High-throughput

0.426

High

652214

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

1

High-throughput

0.407

High

722524

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.407

High

870261

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.407

High

870378

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.407

High

886098

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.407

High

912694

CTR2
Cationic amino acid transporter 2

1

2

High-throughput

0.407

High

1101578

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.407

High

1246086

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.407

High

1322198

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.407

High

1108956

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1234447

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.316

High

1322205

MS4A3
Membrane-spanning 4-domains subfamily A member 3

2

0

High-throughput

0.316

High

1322213

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

1251664

T184A
Transmembrane protein 184A

2

0

High-throughput

0.313

High

260906

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

820562

GPV
Platelet glycoprotein V

1

0

High-throughput

0.279

Low

906317

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

1083272

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.279

Low

1134125

NTCP
Hepatic sodium/bile acid cotransporter

1

0

High-throughput

0.279

Low

1159938

MEA1
Male-enhanced antigen 1

1

0

High-throughput

0.279

Low

1322190

GNT2A
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

1

0

High-throughput

0.279

Low

1322206

SERC2
Serine incorporator 2

1

0

High-throughput

0.279

Low

449529

LIPL
Lipoprotein lipase

1

0

High-throughput

0.268

Low

1007130

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.268

Low

1322196

BRK1
Protein BRICK1

1

0

High-throughput

0.268

Low

390661

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.249

Low

589130

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

675077

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.249

Low

695915

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768624

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

820685

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.249

Low

831047

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

900913

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.249

Low

906904

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.249

Low

1254590

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1293065

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1322215

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1322218

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1322220

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.249

Low

67077

S38A8
Solute carrier family 38 member 8

1

0

High-throughput

0.232

Low

1280792

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

1312947

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.232

Low

1322209

HAUS7
HAUS augmin-like complex subunit 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025