HitPredict

Interactor 1: CD40L (P29965)
CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
Gene: CD40LG

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17567982, 16099873
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 619
+	Hs
		155683 TNF11_HUMAN (20-261): 1.81e-83: 254: 22.46		NFAC3_HUMAN (1-610): 1.34e-128: 406: 15.35
+	Mm
		420397 TNFA_MOUSE (87-261): 6.05e-44: 150: 18.48		TF65_MOUSE (2-576): 1.99e-167: 490: 38.89
+	Hs
		352589 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		TF65_HUMAN (2-576): 4.74e-158: 466: 37.89
+	Hs
		669883 CD40L_HUMAN (1-261): 5.82e-116: 334: 100.00		NFAC2_HUMAN (1-504): 1.26e-88: 296: 14.84
+	Mm
		420392 TNFA_MOUSE (87-261): 6.05e-44: 150: 18.48		NFKB1_MOUSE (1-414): 1.82e-152: 465: 33.56
+	Hs
		352584 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		RELB_HUMAN (2-479): 1.52e-143: 430: 35.04
+	Hs
		317913 CD40L_HUMAN (1-261): 5.82e-116: 334: 100.00		NFAC1_HUMAN (1-486): 1.55e-76: 264: 15.32
+	Mm
		420398 TNFA_MOUSE (87-261): 6.05e-44: 150: 18.48		RELB_MOUSE (2-479): 6.01e-144: 430: 35.25
+	Hs
		352598 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		NFAC3_HUMAN (1-610): 1.34e-128: 406: 15.35
+	Mm
		78126 TNFA_MOUSE (87-261): 6.05e-44: 150: 18.48		B5B2U4_MOUSE (1-604): 6.93e-120: 383: 14.87
+	Mm
		420412 TNFA_MOUSE (87-261): 6.05e-44: 150: 18.48		NFAT5_MOUSE (2-605): 1.99e-104: 348: 14.98
+	Hs
		300514 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		NFAT5_HUMAN (2-605): 1.57e-93: 317: 14.44
+	Hs
		352617 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		NFAC4_HUMAN (1-491): 7.19e-90: 299: 14.43
+	Hs
		352606 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		NFAC2_HUMAN (1-504): 1.26e-88: 296: 14.84
+	Hs
		317883 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		NFAC1_HUMAN (1-486): 1.55e-76: 264: 15.32