Protein: MCM6
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)

Gene: MCM6
Organism: Homo sapiens
Interactions: 243
UniProt ID: Q14566

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region
GO:0003678 - DNA helicase activity
GO:0003697 - single-stranded DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888064

MCM2
DNA replication licensing factor MCM2

18

20

Small-scale

0.988

High

755708

MCM4
DNA replication licensing factor MCM4

12

19

Small-scale

0.976

High

756194

MCM7
DNA replication licensing factor MCM7

11

20

Small-scale

0.975

High

669901

MCM3
DNA replication licensing factor MCM3

8

20

Small-scale

0.970

High

1128286

CDT1
DNA replication factor Cdt1

6

7

Small-scale

0.952

High

1128194

MCM6
DNA replication licensing factor MCM6

5

20

Small-scale

0.928

High

755920

MCM5
DNA replication licensing factor MCM5

5

20

Small-scale

0.915

High

281208

CDC45
Cell division control protein 45 homolog

3

18

Small-scale

0.835

High

1128228

MCM10
Protein MCM10 homolog

7

14

High-throughput

0.753

High

1128270

MCMBP
Mini-chromosome maintenance complex-binding protein

6

19

Small-scale

0.746

High

1050419

UBE3A
Ubiquitin-protein ligase E3A

4

9

Small-scale

0.718

High

1128294

ASF1B
Histone chaperone ASF1B

5

11

Small-scale

0.714

High

1065195

SSRP1
FACT complex subunit SSRP1

4

13

Small-scale

0.697

High

979651

H4
Histone H4

4

8

Small-scale

0.694

High

1128246

ING5
Inhibitor of growth protein 5

3

3

Small-scale

0.669

High

591647

H2AX
Histone H2AX

3

20

High-throughput

0.667

High

1128254

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.667

High

1128316

ASF1A
Histone chaperone ASF1A

3

11

Small-scale

0.667

High

919963

PLK1
Serine/threonine-protein kinase PLK1

3

10

Small-scale

0.656

High

998315

H31
Histone H3.1

3

20

High-throughput

0.656

High

1128261

TONSL
Tonsoku-like protein

3

10

Small-scale

0.656

High

1128269

PSF3
DNA replication complex GINS protein PSF3

1

10

Small-scale

0.647

High

259947

BRD4
Bromodomain-containing protein 4

3

11

High-throughput

0.640

High

372026

MYC
Myc proto-oncogene protein

3

7

High-throughput

0.640

High

1099889

TIF1B
Transcription intermediary factor 1-beta

2

17

Small-scale

0.624

High

231478

ORC4
Origin recognition complex subunit 4

1

20

Small-scale

0.621

High

1128268

SLD5
DNA replication complex GINS protein SLD5

1

17

Small-scale

0.618

High

1128308

MCM8
DNA helicase MCM8

1

20

Small-scale

0.618

High

418983

H2A1B
Histone H2A type 1-B/E

2

20

High-throughput

0.611

High

1128266

SPI2B
Spindlin-2B

2

3

High-throughput

0.611

High

132477

CDC7
Cell division cycle 7-related protein kinase

2

20

Small-scale

0.602

High

1128304

DBF4A
Protein DBF4 homolog A

2

6

Small-scale

0.602

High

1128195

SMC1A
Structural maintenance of chromosomes protein 1A

2

11

Small-scale

0.601

High

695456

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

Small-scale

0.586

High

842758

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

7

Small-scale

0.586

High

241683

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

315585

RECQ4
ATP-dependent DNA helicase Q4

2

15

Small-scale

0.584

High

588696

RFA2
Replication protein A 32 kDa subunit

2

6

Small-scale

0.584

High

830734

CCNF
Cyclin-F

2

12

High-throughput

0.584

High

1067327

EP300
Histone acetyltransferase p300

2

12

High-throughput

0.584

High

1128282

SPRTN
DNA-dependent metalloprotease SPRTN

2

5

Small-scale

0.584

High

1128215

ESCO2
N-acetyltransferase ESCO2

1

7

Small-scale

0.573

High

471835

RU2B
U2 small nuclear ribonucleoprotein B''

1

7

High-throughput

0.573

High

163106

CHK1
Serine/threonine-protein kinase Chk1

1

5

Small-scale

0.561

High

1128245

ATRIP
ATR-interacting protein

1

4

Small-scale

0.561

High

619795

VCAM1
Vascular cell adhesion protein 1

2

8

High-throughput

0.549

High

1128211

F161A
Protein FAM161A

1

0

High-throughput

0.549

High

1128257

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.549

High

415570

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.541

High

680873

PSA1
Proteasome subunit alpha type-1

1

2

High-throughput

0.541

High

839885

AF9
Protein AF-9

1

1

High-throughput

0.541

High

1007639

CCNA1
Cyclin-A1

1

5

High-throughput

0.536

High

1128320

ORC6
Origin recognition complex subunit 6

1

4

High-throughput

0.536

High

291793

STK16
Serine/threonine-protein kinase 16

1

10

High-throughput

0.536

High

361248

SODC
Superoxide dismutase [Cu-Zn]

1

4

High-throughput

0.536

High

363293

EGFR
Epidermal growth factor receptor

1

9

Small-scale

0.536

High

455769

H10
Histone H1.0

1

3

High-throughput

0.536

High

484533

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

487313

PARP1
Poly [ADP-ribose] polymerase 1

1

10

High-throughput

0.536

High

501985

H2AZ
Histone H2A.Z

1

20

High-throughput

0.536

High

542021

TOP1
DNA topoisomerase 1

1

7

High-throughput

0.536

High

563768

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

570887

MIF
Macrophage migration inhibitory factor

1

3

High-throughput

0.536

High

601670

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

854054

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

1013052

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.536

High

1016858

H33
Histone H3.3

1

20

High-throughput

0.536

High

1113105

CUL3
Cullin-3

1

9

High-throughput

0.536

High

1128197

NUMA1
Nuclear mitotic apparatus protein 1

1

15

High-throughput

0.536

High

1128209

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1128225

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

5

High-throughput

0.536

High

1128251

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.536

High

1128255

SGK3
Serine/threonine-protein kinase Sgk3

1

3

High-throughput

0.536

High

1128279

FOXQ1
Forkhead box protein Q1

1

8

High-throughput

0.536

High

1128285

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1128307

TRPS1
Zinc finger transcription factor Trps1

1

1

High-throughput

0.536

High

1128317

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

5

Small-scale

0.536

High

1128274

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.518

High

284314

GEMI
Geminin

1

0

High-throughput

0.513

High

1128204

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

955168

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.501

High

1089400

ILF2
Interleukin enhancer-binding factor 2

1

8

Small-scale

0.500

High

1128272

TIPIN
TIMELESS-interacting protein

1

7

Small-scale

0.500

High

1128302

I36RA
Interleukin-36 receptor antagonist protein

1

1

High-throughput

0.494

High

389362

FINC
Fibronectin

1

6

High-throughput

0.489

High

724071

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.489

High

1013297

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

1104308

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.481

High

1104341

ORC2
Origin recognition complex subunit 2

1

9

Small-scale

0.481

High

61741

SBNO1
Protein strawberry notch homolog 1

1

2

High-throughput

0.479

High

126596

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.479

High

180814

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.479

High

216437

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.479

High

223039

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

231142

AIRE
Autoimmune regulator

1

20

Small-scale

0.479

High

243937

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

16

High-throughput

0.479

High

256856

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

272171

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.479

High

345816

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.479

High

347706

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

349997

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

385740

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

11

High-throughput

0.479

High

411930

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

413827

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

540017

BCR
Breakpoint cluster region protein

1

8

High-throughput

0.479

High

606766

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

613034

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

639244

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

6

High-throughput

0.479

High

659476

CRCM
Colorectal mutant cancer protein

1

12

High-throughput

0.479

High

664740

CCND1
G1/S-specific cyclin-D1

1

9

Small-scale

0.479

High

667851

CDK2
Cyclin-dependent kinase 2

1

11

High-throughput

0.479

High

681368

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

731294

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

754842

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

766553

PHB1
Prohibitin 1

1

7

High-throughput

0.479

High

768190

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

799114

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

855444

ATRX
Transcriptional regulator ATRX

1

13

Small-scale

0.479

High

879086

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.479

High

883243

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

8

High-throughput

0.479

High

891548

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.479

High

894745

EMD
Emerin

1

2

Small-scale

0.479

High

910050

RND2
Rho-related GTP-binding protein RhoN

1

3

High-throughput

0.479

High

928624

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.479

High

957379

UBC12
NEDD8-conjugating enzyme Ubc12

1

8

High-throughput

0.479

High

970496

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

1026379

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

1045282

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1057456

SOX4
Transcription factor SOX-4

1

10

High-throughput

0.479

High

1088839

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1091100

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

1091398

ANK3
Ankyrin-3

1

3

High-throughput

0.479

High

1105920

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

13

High-throughput

0.479

High

1106862

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1121211

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

1126879

RBM39
RNA-binding protein 39

1

9

High-throughput

0.479

High

1128196

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

6

High-throughput

0.479

High

1128198

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

4

High-throughput

0.479

High

1128199

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

7

High-throughput

0.479

High

1128200

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1128201

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1128202

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.479

High

1128206

EZH2
Histone-lysine N-methyltransferase EZH2

1

10

High-throughput

0.479

High

1128207

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

1128208

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.479

High

1128210

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1128216

ESCO1
N-acetyltransferase ESCO1

1

8

Small-scale

0.479

High

1128219

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

1128220

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

1128222

MMS22
Protein MMS22-like

1

3

Small-scale

0.479

High

1128224

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.479

High

1128226

MOB3C
MOB kinase activator 3C

1

6

High-throughput

0.479

High

1128227

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

1128229

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1128230

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

4

High-throughput

0.479

High

1128231

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1128232

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

11

Small-scale

0.479

High

1128234

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.479

High

1128238

SIR6
NAD-dependent protein deacylase sirtuin-6

1

14

High-throughput

0.479

High

1128241

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

11

Small-scale

0.479

High

1128242

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1128247

TOPB1
DNA topoisomerase 2-binding protein 1

1

8

High-throughput

0.479

High

1128248

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1128249

REQU
Zinc finger protein ubi-d4

1

15

High-throughput

0.479

High

1128250

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

1128252

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

1128253

FBXW7
F-box/WD repeat-containing protein 7

1

6

High-throughput

0.479

High

1128258

ARMC5
Armadillo repeat-containing protein 5

1

10

High-throughput

0.479

High

1128264

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1128265

BARD1
BRCA1-associated RING domain protein 1

1

10

High-throughput

0.479

High

1128267

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

1128271

DUS23
Dual specificity protein phosphatase 23

1

16

High-throughput

0.479

High

1128273

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

18

Small-scale

0.479

High

1128275

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1128276

FACD2
Fanconi anemia group D2 protein

1

10

Small-scale

0.479

High

1128281

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

6

High-throughput

0.479

High

1128284

CCDC8
Coiled-coil domain-containing protein 8

1

8

High-throughput

0.479

High

1128289

ECT2
Protein ECT2

1

12

High-throughput

0.479

High

1128290

PRD16
Histone-lysine N-methyltransferase PRDM16

1

2

High-throughput

0.479

High

1128291

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.479

High

1128292

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

High-throughput

0.479

High

1128293

DUS22
Dual specificity protein phosphatase 22

1

7

High-throughput

0.479

High

1128295

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

1128296

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

2

High-throughput

0.479

High

1128297

DONS
Protein downstream neighbor of Son

1

4

Small-scale

0.479

High

1128298

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.479

High

1128299

PD1L1
Programmed cell death 1 ligand 1

1

4

Small-scale

0.479

High

1128301

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

6

High-throughput

0.479

High

1128303

POLK
DNA polymerase kappa

1

3

Small-scale

0.479

High

1128305

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1128306

UBQL2
Ubiquilin-2

1

9

High-throughput

0.479

High

1128309

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.479

High

1128310

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

3

High-throughput

0.479

High

1128311

TRI33
E3 ubiquitin-protein ligase TRIM33

1

15

High-throughput

0.479

High

1128312

SRRM2
Serine/arginine repetitive matrix protein 2

1

4

High-throughput

0.479

High

1128313

CD11A
Cyclin-dependent kinase 11A

1

12

High-throughput

0.479

High

1128314

SMC3
Structural maintenance of chromosomes protein 3

1

11

High-throughput

0.479

High

1128315

HDAC5
Histone deacetylase 5

1

15

High-throughput

0.479

High

1128318

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

High-throughput

0.479

High

1128319

TRAF6
TNF receptor-associated factor 6

1

7

High-throughput

0.479

High

1128321

NS1BP
Influenza virus NS1A-binding protein

1

10

High-throughput

0.479

High

567398

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

719145

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.458

High

1091608

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

1128259

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.458

High

697111

APEX1
DNA repair nuclease/redox regulator APEX1

1

5

Small-scale

0.445

High

1128217

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

1128218

Q5T670
Protein MCM10 homolog

1

14

High-throughput

0.445

High

1128233

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

1128263

TNIP3
TNFAIP3-interacting protein 3

1

9

High-throughput

0.445

High

1128280

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

318770

RHBT1
Rho-related BTB domain-containing protein 1

1

7

High-throughput

0.437

High

380029

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.437

High

565383

ITA4
Integrin alpha-4

1

5

High-throughput

0.437

High

1128203

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.437

High

1128212

ANR55
Ankyrin repeat domain-containing protein 55

1

9

High-throughput

0.437

High

1128213

DUS28
Dual specificity phosphatase 28

1

7

High-throughput

0.437

High

1128223

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

1128235

RHG24
Rho GTPase-activating protein 24

1

11

High-throughput

0.437

High

1128237

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1128240

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

1128243

DUS19
Dual specificity protein phosphatase 19

1

7

High-throughput

0.437

High

1128244

DEP1B
DEP domain-containing protein 1B

1

7

High-throughput

0.437

High

1128256

ATG2B
Autophagy-related protein 2 homolog B

1

3

High-throughput

0.437

High

1128277

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1128278

RHBT2
Rho-related BTB domain-containing protein 2

1

7

High-throughput

0.437

High

1128287

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

1128300

RELCH
RAB11-binding protein RELCH

1

2

High-throughput

0.437

High

1128260

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

62519

S35F4
Solute carrier family 35 member F4

1

3

High-throughput

0.407

High

133509

ACATN
Acetyl-coenzyme A transporter 1

1

4

High-throughput

0.407

High

906276

GPC3
Glypican-3

1

1

High-throughput

0.407

High

1128205

UT2
Urea transporter 2

1

1

High-throughput

0.407

High

1128236

SVOPL
Putative transporter SVOPL

1

1

High-throughput

0.407

High

1128239

S35G3
Solute carrier family 35 member G3

1

2

High-throughput

0.407

High

1128262

S45A3
Solute carrier family 45 member 3

1

3

High-throughput

0.407

High

1128283

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

3

High-throughput

0.407

High

897123

AP4A
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

1

0

High-throughput

0.299

High

1128214

CTSRT
Cation channel sperm-associated targeting subunit tau

1

0

High-throughput

0.282

High

1128221

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1127883

S29A2
Equilibrative nucleoside transporter 2

1

0

High-throughput

0.232

Low

1128288

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025