HitPredict

Interactor 1: CD40L (P29965)
CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
Gene: CD40LG

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23918987
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 604
+	Hs
		669885 CD40L_HUMAN (1-261): 5.82e-116: 334: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		352607 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	Hs
		352608 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		207235 TNF14_HUMAN (113-261): 9.8e-47: 157: 22.64		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		352415 TNFB_HUMAN (92-261): 2.29e-37: 132: 18.08		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		352678 TNFA_HUMAN (87-261): 1.96e-52: 172: 21.20		MIB2_HUMAN (544-603): 2.9e-10: 65.3: 35.00