HitPredict

Interactor 1: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Interactor 2: KEAP1 (Q14145)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
Gene: KEAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	27621311, 30108253, 28416489, 30126895, 37365714, 23382044, 24322982
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 808 Hs			1 624
+	Mm
		670064 MCM3_MOUSE (1-808): 0: 922: 92.64		KEAP1_MOUSE (1-624): 0: 577: 94.07
+	Hs
		888052 MCM2_HUMAN (10-721): 0: 707: 30.62		KEAP1_HUMAN (1-624): 0: 582: 100.00
+	Mm
		1021137 MCM6_MOUSE (2-800): 0: 693: 26.53		KEAP1_MOUSE (1-624): 0: 577: 94.07
+	Mm
		887492 MCM4_MOUSE (9-739): 0: 664: 28.29		KEAP1_MOUSE (1-624): 0: 577: 94.07
+	Dm
		1473015 MCM3_DROME (12-808): 0: 856: 61.35		Q9VEN5_DROME (423-623): 4.86e-50: 187: 31.71
+	Dm
		1269044 MCM3_DROME (12-808): 0: 856: 61.35		Q7KSF5_DROME (423-623): 9.22e-50: 186: 31.71