Protein: KEAP1
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2)

Gene: KEAP1
Organism: Mus musculus
Interactions: 22
UniProt ID: Q9Z2X8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491930

KEAP1
Kelch-like ECH-associated protein 1

3

20

Small-scale

0.863

High

1221503

NF2L2
Nuclear factor erythroid 2-related factor 2

24

10

Small-scale

0.767

High

1440934

CUL3
Cullin-3

2

20

Small-scale

0.754

High

1225686

SQSTM
Sequestosome-1

3

6

Small-scale

0.681

High

509340

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

8

High-throughput

0.647

High

1190769

Q3UQ17
Zinc finger and BTB domain containing 16

1

0

Small-scale

0.586

High

1223112

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.536

High

670064

MCM3
DNA replication licensing factor MCM3

1

7

Small-scale

0.501

High

684928

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha]

1

2

Small-scale

0.501

High

1021137

MCM6
DNA replication licensing factor MCM6

1

7

Small-scale

0.501

High

1246831

NEIL2
Endonuclease 8-like 2

1

1

Small-scale

0.501

High

1341556

MCMBP
Mini-chromosome maintenance complex-binding protein

1

1

Small-scale

0.501

High

944144

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

15

Small-scale

0.479

High

1022066

BRCA2
Breast cancer type 2 susceptibility protein homolog

1

1

Small-scale

0.479

High

1282784

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

1362953

TRI59
Tripartite motif-containing protein 59

1

5

Small-scale

0.479

High

887492

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.457

High

1223395

MCM7
DNA replication licensing factor MCM7

1

5

Small-scale

0.457

High

312176

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

High-throughput

0.457

High

1222332

ASTN1
Astrotactin-1

1

1

Small-scale

0.437

High

1242563

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025