HitPredict

Interactor 1: MARCS (P29966)
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene: MARCKS

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0006915 - apoptotic process GO:0007015 - actin filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 332 Hs			1 196
+	Hs
		669970 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		166043 SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		669956 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		545219 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		436170 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		669979 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		669952 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		669953 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		166039 SYNJ2_HUMAN (63-316): 5.31e-21: 96: 9.20		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		297823 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		297820 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67
+	Hs
		297822 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00
+	Hs
		297812 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		564421 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		297809 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16
+	Hs
		297827 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		120313 MARCS_HUMAN (1-322): 2.14e-23: 100: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		297819 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Ce
		104464 UNC89_CAEEL (97-332): 8.9e-11: 65.3: 12.29		G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72
+	Hs
		120250 K0754_HUMAN (52-332): 1.35e-14: 77.1: 16.38		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98