HitPredict

Interactor 1: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	26496610, 31478661
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 256 Hs			1 191
+	Hs
		670928 PRDX3_HUMAN (1-256): 3.48e-122: 349: 100.00		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		685658 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		545224 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436174 PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		893930 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		545338 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436270 PRDX1_HUMAN (63-253): 1.5e-100: 293: 63.54		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41