HitPredict

Interactor 1: PDIA3 (P30101)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
Gene: PDIA3

Interactor 2: CALR3 (Q96L12)
Calreticulin-3 (Calreticulin-2) (Calsperin)
Gene: CALR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31056421, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Calreticulin~Thioredoxin_6
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 384
+	Hs
		653491 PDIA3_HUMAN (1-505): 6.41e-165: 478: 100.00		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		423330 PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		654099 PDIA3_HUMAN (1-505): 6.41e-165: 478: 100.00		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Rn
		514119 PDIA3_RAT (1-505): 1.85e-160: 466: 92.28		CALX_RAT (16-357): 1.96e-122: 367: 26.97
+	Mm
		1322122 PDILT_MOUSE (1-494): 2.75e-78: 257: 20.39		CALR3_MOUSE (1-384): 0: 523: 82.60
+	Dm
		667020 Q3YMU0_DROME (1-500): 1.45e-116: 354: 44.64		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Dm
		667013 PDI_DROME (1-489): 4.24e-108: 332: 31.65		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		423150 PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		1220455 DJC10_HUMAN (27-244): 3.4e-31: 129: 17.39		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		1296643 ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Mm
		852408 PDILT_MOUSE (1-494): 2.75e-78: 257: 20.39		CLGN_MOUSE (20-336): 2.44e-111: 340: 26.28
+	Hs
		653650 DJC10_HUMAN (27-244): 3.4e-31: 129: 17.39		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653695 TMX3_HUMAN (375-482): 4.46e-27: 115: 37.27		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653711 ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		531728 PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653575 PDIA2_HUMAN (356-501): 1e-23: 106: 22.30		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		654519 DJC10_HUMAN (27-244): 3.4e-31: 129: 17.39		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654668 TMX3_HUMAN (375-482): 4.46e-27: 115: 37.27		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654706 ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		531729 PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73