HitPredict

Interactor 1: 2AAA (P30153)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: PPP2R1A

Interactor 2: 2A5E (Q16537)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon)
Gene: PPP2R5E

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.976

Property	Details
Experiments	27173435, 23555304, 26496610, 28330616, 18782753, 33961781, 19156129, 23443559
Identification Methods	affinity chromatography technology, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	B56~HEAT_2
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019888 - protein phosphatase regulator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 589 Hs			1 467
+	Hs
		672428 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5E_HUMAN (1-467): 0: 773: 100.00
+	Hs
		672123 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5D_HUMAN (4-454): 0: 708: 67.91
+	Hs
		672129 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5A_HUMAN (12-434): 0: 705: 80.43
+	Hs
		672130 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5B_HUMAN (2-463): 0: 696: 71.92
+	Hs
		672422 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5D_HUMAN (4-454): 0: 708: 67.91
+	Hs
		672107 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		2A5G_HUMAN (38-457): 0: 685: 70.76
+	Hs
		672425 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5A_HUMAN (12-434): 0: 705: 80.43
+	Hs
		672187 2AAA_HUMAN (1-589): 2.84e-166: 487: 100.00		Q7L7W2_HUMAN (38-457): 0: 682: 70.76
+	Hs
		672426 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5B_HUMAN (2-463): 0: 696: 71.92
+	Hs
		672415 2AAB_HUMAN (9-589): 7.23e-158: 466: 86.40		2A5G_HUMAN (38-457): 0: 685: 70.76
+	Dm
		47131 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		A0A6F7R657_DROME (2-463): 0: 714: 74.51
+	Dm
		734216 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		Q9VEC6_DROME (48-457): 0: 712: 68.77
+	Dm
		734212 2AAA_DROME (1-578): 2.84e-146: 436: 75.35		Q9VB23_DROME (11-463): 0: 704: 75.77
+	At
		1104795 2AAA_ARATH (92-587): 3.85e-48: 178: 17.74		2A5G_ARATH (32-465): 0: 712: 51.25
+	At
		1105298 2AAB_ARATH (92-587): 9.45e-46: 172: 18.15		2A5N_ARATH (18-458): 0: 715: 53.59
+	At
		1105306 2AAG_ARATH (92-587): 7.34e-45: 169: 17.74		2A5N_ARATH (18-458): 0: 715: 53.59
+	At
		138268 2AAA_ARATH (92-587): 3.85e-48: 178: 17.74		2A5B_ARATH (44-457): 0: 690: 53.94
+	Ce
		999428 2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85		Q17948_CAEEL (5-457): 0: 685: 60.44
+	Ce
		999433 2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85		Q9U3Q1_CAEEL (26-457): 0: 684: 63.16
+	Ce
		110946 2AAA_CAEEL (92-589): 2.72e-42: 162: 18.85		H9G2X3_CAEEL (5-457): 0: 683: 60.44