Protein: ERG4
Delta(24(24(1)))-sterol reductase ERG4 (EC 1.3.1.71) (C-24(28) sterol reductase ERG4) (Ergosterol biosynthetic protein 4) (Sterol Delta(24(28))-reductase ERG4)

Gene: ERG4
Organism: Saccharomyces cerevisiae S288C
Interactions: 64
UniProt ID: P25340

Gene Ontology (top 5):
GO:0000246 - Delta24(24-1) sterol reductase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006696 - ergosterol biosynthetic process
GO:0050614 - Delta24-sterol reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

672137

ERG24
Delta(14)-sterol reductase ERG24

2

3

Small-scale

0.793

High

672132

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

3

Small-scale

0.698

High

528552

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

Small-scale

0.541

High

668879

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

672138

ERG1
Squalene epoxidase ERG1

1

1

Small-scale

0.541

High

672157

ERG28
Ergosterol biosynthetic protein 28

1

1

Small-scale

0.541

High

672164

ERG25
C-4 methylsterol oxidase ERG25

1

1

Small-scale

0.541

High

672166

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

3

Small-scale

0.541

High

672171

ERG5
C-22 sterol desaturase ERG5

1

1

Small-scale

0.541

High

672180

ERG27
3-keto-steroid reductase ERG27

1

2

Small-scale

0.541

High

523153

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.533

High

543920

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.521

High

672140

HSP7F
Heat shock protein homolog SSE1

2

4

High-throughput

0.521

High

672153

BSD2
Metal homeostatis protein BSD2

1

0

High-throughput

0.518

High

672155

NSG1
Protein NSG1

1

0

High-throughput

0.518

High

672163

SC6B1
Protein transport protein SBH1

1

1

Small-scale

0.481

High

554311

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

2

High-throughput

0.479

High

554398

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

2

High-throughput

0.479

High

577041

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.479

High

672134

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

672136

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

High-throughput

0.479

High

672141

EMP24
Endosomal protein P24B

1

1

High-throughput

0.479

High

672142

SRPR
Signal recognition particle receptor subunit alpha homolog

1

1

High-throughput

0.479

High

672147

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

High-throughput

0.479

High

672148

YET1
Endoplasmic reticulum transmembrane protein 1

1

3

High-throughput

0.479

High

672158

ELO3
Fatty acid elongase 3

1

2

High-throughput

0.479

High

672160

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

672162

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

2

High-throughput

0.479

High

672176

YET3
Endoplasmic reticulum transmembrane protein 3

1

3

High-throughput

0.479

High

672135

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

672143

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.458

High

672145

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

672146

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.458

High

672149

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

672151

YBU6
Probable thioesterase YBR096W

1

0

High-throughput

0.458

High

672152

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

672154

LAG1
Ceramide synthase LAG1

1

0

High-throughput

0.458

High

672165

ERV14
ER-derived vesicles protein ERV14

1

0

High-throughput

0.458

High

672167

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.458

High

672168

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

672169

PGA2
Processing of GAS1 and ALP protein 2

1

0

High-throughput

0.458

High

672172

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.458

High

672175

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

672181

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

0

High-throughput

0.458

High

672182

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.458

High

526001

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.437

High

592036

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.437

High

672133

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.437

High

672150

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

672170

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.437

High

672156

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.407

High

672173

STE20
Serine/threonine-protein kinase STE20

2

0

Small-scale

0.320

High

672174

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

0

High-throughput

0.282

High

672177

FMP25
Protein FMP25, mitochondrial

1

0

High-throughput

0.282

High

94537

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

382837

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

578908

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

672139

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

672161

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.249

Low

672178

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.249

Low

672179

GNT1
Glucose N-acetyltransferase 1

1

0

High-throughput

0.249

Low

672144

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

672159

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025