Protein: DHCR7
7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Cholesterol-5,6-epoxide hydrolase subunit DHCR7) (EC 3.3.2.11) (Sterol Delta(7)-reductase)

Gene: DHCR7
Organism: Mus musculus
Interactions: 89
UniProt ID: O88455

Gene Ontology (top 5):
GO:0001568 - blood vessel development
GO:0005789 - endoplasmic reticulum membrane
GO:0006695 - cholesterol biosynthetic process
GO:0009791 - post-embryonic development
GO:0016126 - sterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

312245

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

4

High-throughput

0.479

High

312253

CALX
Calnexin

1

2

High-throughput

0.479

High

312263

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

1

High-throughput

0.479

High

312268

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

312270

ESYT2
Extended synaptotagmin-2

1

2

High-throughput

0.479

High

312277

KTN1
Kinectin

1

1

High-throughput

0.479

High

312288

Q8BH80
Vesicle-associated membrane protein, associated protein B and C

1

3

High-throughput

0.479

High

312291

CKAP4
Cytoskeleton-associated protein 4

1

4

High-throughput

0.479

High

312292

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

312294

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

312303

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

312304

LRC59
Leucine-rich repeat-containing protein 59 [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed]

1

2

High-throughput

0.479

High

312308

RRBP1
Ribosome-binding protein 1

1

3

High-throughput

0.479

High

312319

AT131
Endoplasmic reticulum transmembrane helix translocase

1

2

High-throughput

0.479

High

312321

JPH3
Junctophilin-3

1

1

High-throughput

0.479

High

312326

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.479

High

266735

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.458

High

312257

WFS1
Wolframin

1

0

High-throughput

0.458

High

312264

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

312267

EMC10
ER membrane protein complex subunit 10

1

0

High-throughput

0.458

High

312284

ASTRB
Protein Aster-B

1

0

High-throughput

0.458

High

312287

LYRIC
Protein LYRIC

1

0

High-throughput

0.458

High

312289

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.458

High

312290

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

312296

HACD3
Very-long-chain

1

0

High-throughput

0.458

High

312298

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.458

High

312299

UBXN4
UBX domain-containing protein 4

1

0

High-throughput

0.458

High

312312

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

312315

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

312316

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

64319

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

5

High-throughput

0.437

High

73141

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

1

High-throughput

0.437

High

147618

EMD
Emerin

1

2

High-throughput

0.437

High

312249

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.437

High

312251

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.437

High

312252

PLAP
Phospholipase A-2-activating protein

1

4

High-throughput

0.437

High

312255

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

1

High-throughput

0.437

High

312256

PRS6B
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.437

High

312258

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.437

High

312265

KCNB1
Potassium voltage-gated channel subfamily B member 1

1

5

High-throughput

0.437

High

312266

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.437

High

312269

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.437

High

312278

BTF3
Transcription factor BTF3

1

2

High-throughput

0.437

High

312282

AMPH
Amphiphysin

1

2

High-throughput

0.437

High

312283

KCNF1
Voltage-gated potassium channel regulatory subunit KCNF1

1

5

High-throughput

0.437

High

312286

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.437

High

312295

TXNL1
Thioredoxin-like protein 1

1

1

High-throughput

0.437

High

312301

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.437

High

312310

BT3L4
Transcription factor BTF3 homolog 4

1

2

High-throughput

0.437

High

312318

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.437

High

312320

STRN3
Striatin-3

1

3

High-throughput

0.437

High

312322

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

1

High-throughput

0.437

High

312325

PCLO
Protein piccolo

1

2

High-throughput

0.437

High

204481

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.249

Low

237002

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.249

Low

267228

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.249

Low

312246

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

312247

GLNA
Glutamine synthetase

1

0

High-throughput

0.249

Low

312248

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.249

Low

312250

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.249

Low

312254

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.249

Low

312259

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.249

Low

312260

GBRB3
Gamma-aminobutyric acid receptor subunit beta-3

1

0

High-throughput

0.249

Low

312261

KCNJ3
G protein-activated inward rectifier potassium channel 1

1

0

High-throughput

0.249

Low

312262

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.249

Low

312271

EDC4
Enhancer of mRNA-decapping protein 4

1

0

High-throughput

0.249

Low

312272

Q3UZG4
Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

1

0

High-throughput

0.249

Low

312273

VEZA
Vezatin

1

0

High-throughput

0.249

Low

312274

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.249

Low

312275

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.249

Low

312276

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.249

Low

312279

SQSTM
Sequestosome-1

1

0

High-throughput

0.249

Low

312280

SPKAP
A-kinase anchor protein SPHKAP

1

0

High-throughput

0.249

Low

312281

ANO8
Anoctamin-8

1

0

High-throughput

0.249

Low

312285

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.249

Low

312293

DZAN1
Double zinc ribbon and ankyrin repeat-containing protein 1

1

0

High-throughput

0.249

Low

312297

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

312300

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.249

Low

312302

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.249

Low

312305

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.249

Low

312306

F10A1
Hsc70-interacting protein

1

0

High-throughput

0.249

Low

312307

Q99N15
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.249

Low

312309

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

312311

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

High-throughput

0.249

Low

312313

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.249

Low

312314

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.249

Low

312317

ADCK1
AarF domain-containing protein kinase 1

1

0

High-throughput

0.249

Low

312323

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.249

Low

312324

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025