HitPredict

Interactor 1: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Interactor 2: RBL2 (Q08999)
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
Gene: RBL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	26186194, 28514442, 10572252, 33961781, 16600870
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 1139
+	Hs
		622439 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		943777 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		538529 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		590169 CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		673066 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		660112 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		331639 CCNE2_HUMAN (13-243): 1.83e-18: 86.7: 27.47		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		624579 CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13		RBL2_HUMAN (1-1139): 0: 1591: 100.00
+	Hs
		590128 CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		624544 CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		414169 CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414240 CCNA1_HUMAN (4-283): 4.44e-93: 284: 25.89		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414150 CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Mm
		527133 CCND3_MOUSE (1-292): 1.71e-86: 262: 94.52		RB_MOUSE (762-1032): 6.63e-68: 248: 27.24
+	Hs
		414164 CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Mm
		527131 CCND1_MOUSE (2-292): 1.72e-85: 259: 51.86		RB_MOUSE (762-1032): 6.63e-68: 248: 27.24
+	Hs
		414188 CCND3_HUMAN (1-292): 8.61e-89: 267: 100.00		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414187 CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414171 CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Dm
		872346 CCNE_DROME (52-166): 1.86e-15: 78.2: 34.48		RBF_DROME (828-1097): 1.21e-42: 170: 26.81