Protein: DBP4
ATP-dependent RNA helicase HCA4 (EC 3.6.4.13) (DEAD box protein 4) (Helicase CA4) (Helicase UF1)

Gene: DBP4, HCA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 203
UniProt ID: P20448

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

632727

HAS1
ATP-dependent RNA helicase HAS1

4

18

High-throughput

0.904

High

632627

PWP2
Periodic tryptophan protein 2

3

17

High-throughput

0.855

High

632612

DBP4
ATP-dependent RNA helicase HCA4

2

17

High-throughput

0.830

High

632692

PFS2
Polyadenylation factor subunit 2

2

18

High-throughput

0.802

High

632733

DHR1
Probable ATP-dependent RNA helicase DHR1

2

11

High-throughput

0.754

High

632685

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

High-throughput

0.753

High

632746

ESF1
Pre-rRNA-processing protein ESF1

4

3

High-throughput

0.705

High

632712

SQS1
Protein SQS1

1

2

High-throughput

0.698

High

632743

SGD1
Suppressor of glycerol defect protein 1

1

3

High-throughput

0.698

High

585203

FBRL
rRNA 2'-O-methyltransferase fibrillarin

4

9

High-throughput

0.696

High

632769

NOP56
Nucleolar protein 56

4

16

High-throughput

0.694

High

600978

RL8A
Large ribosomal subunit protein eL8A

1

14

High-throughput

0.691

High

632657

SWD2
COMPASS component SWD2

1

17

High-throughput

0.691

High

632749

BFR2
Protein BFR2

3

2

Small-scale

0.680

High

632711

ESF2
Pre-rRNA-processing protein ESF2

3

7

Small-scale

0.672

High

632771

NOP58
Nucleolar protein 58

3

16

High-throughput

0.662

High

632770

RRP36
rRNA biogenesis protein RRP36

3

2

Small-scale

0.658

High

632663

ENP1
Essential nuclear protein 1

3

8

High-throughput

0.640

High

632693

UTP10
U3 small nucleolar RNA-associated protein 10

3

5

High-throughput

0.640

High

632709

UTP22
U3 small nucleolar RNA-associated protein 22

2

3

High-throughput

0.637

High

632762

SAS10
Something about silencing protein 10

2

2

High-throughput

0.637

High

403350

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

7

High-throughput

0.621

High

632618

RNA14
mRNA 3'-end-processing protein RNA14

2

10

High-throughput

0.621

High

632625

SRO9
RNA-binding protein SRO9

2

10

High-throughput

0.621

High

632645

PP12
Serine/threonine-protein phosphatase PP1-2

2

5

High-throughput

0.621

High

632648

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

5

High-throughput

0.621

High

632697

FIP1
Pre-mRNA polyadenylation factor FIP1

2

1

High-throughput

0.621

High

632744

YSH1
Endoribonuclease YSH1

2

2

High-throughput

0.621

High

632753

NOP12
Nucleolar protein 12

2

20

High-throughput

0.621

High

632761

CFT2
Cleavage factor two protein 2

2

1

High-throughput

0.621

High

632700

NOL10
Ribosome biogenesis protein ENP2

2

2

Small-scale

0.618

High

632651

DCA13
Protein SOF1

1

17

High-throughput

0.618

High

632655

DOA1
Protein DOA1

1

19

Small-scale

0.618

High

632658

RL1D1
Ribosome biogenesis protein UTP30

1

6

High-throughput

0.618

High

632661

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

632666

DBP8
ATP-dependent RNA helicase DBP8

1

19

High-throughput

0.618

High

632680

UTP7
U3 small nucleolar RNA-associated protein 7

1

17

High-throughput

0.618

High

632696

ROK1
ATP-dependent RNA helicase ROK1

1

16

High-throughput

0.618

High

632702

RS12
Small ribosomal subunit protein eS12

1

6

High-throughput

0.618

High

632724

UTP17
NET1-associated nuclear protein 1

1

15

High-throughput

0.618

High

632734

UTP15
U3 small nucleolar RNA-associated protein 15

1

16

High-throughput

0.618

High

632741

UTP13
U3 small nucleolar RNA-associated protein 13

1

20

High-throughput

0.618

High

632737

UTP14
U3 small nucleolar RNA-associated protein 14

2

4

High-throughput

0.614

High

632630

RS7A
Small ribosomal subunit protein eS7A

2

8

High-throughput

0.611

High

632739

RRP5
rRNA biogenesis protein RRP5

2

9

High-throughput

0.611

High

632714

NAT10
RNA cytidine acetyltransferase

2

6

High-throughput

0.601

High

632747

CORO
Coronin-like protein

1

11

High-throughput

0.595

High

632636

PAP
Poly(A) polymerase

2

0

High-throughput

0.595

High

632679

PTI1
Protein PTI1

2

0

High-throughput

0.595

High

632691

REF2
RNA end formation protein 2

2

0

High-throughput

0.595

High

632719

PTA1
Pre-tRNA-processing protein PTA1

2

0

High-throughput

0.595

High

632642

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

2

14

High-throughput

0.588

High

632659

RPF2
Ribosome biogenesis protein RPF2

2

4

High-throughput

0.588

High

632626

KRR1
KRR1 small subunit processome component

2

10

High-throughput

0.584

High

632668

UTP9
U3 small nucleolar RNA-associated protein 9

2

1

High-throughput

0.584

High

632742

UTP21
U3 small nucleolar RNA-associated protein 21

2

16

Small-scale

0.584

High

632748

NOC4
Nucleolar complex protein 4

2

17

High-throughput

0.584

High

585849

CSK21
Casein kinase II subunit alpha

1

13

High-throughput

0.582

High

632635

RL8B
Large ribosomal subunit protein eL8B

1

14

High-throughput

0.575

High

523030

HSP71
Heat shock protein SSA1

2

15

High-throughput

0.571

High

632617

SIS1
Protein SIS1

2

8

High-throughput

0.571

High

543787

SSB1
Ribosome-associated molecular chaperone SSB1

2

15

High-throughput

0.552

High

632695

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.541

High

432974

RL6B
Large ribosomal subunit protein eL6B

1

8

High-throughput

0.536

High

531599

RL4A
Large ribosomal subunit protein uL4A

1

11

High-throughput

0.536

High

632629

RL16B
Large ribosomal subunit protein uL13B

1

16

High-throughput

0.536

High

632637

XPO1
Exportin-1

1

19

High-throughput

0.536

High

632683

RL13B
Large ribosomal subunit protein eL13B

1

12

High-throughput

0.536

High

632772

RL13A
Large ribosomal subunit protein eL13A

1

12

High-throughput

0.536

High

558576

CAF20
Cap-associated protein CAF20

2

2

High-throughput

0.533

High

632632

SBA1
Co-chaperone protein SBA1

1

3

Small-scale

0.527

High

366768

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.515

High

419591

H2A2
Histone H2A.2

1

10

High-throughput

0.515

High

632613

TRX1
Thioredoxin-1

1

1

High-throughput

0.515

High

632615

BUR1
Serine/threonine-protein kinase BUR1

1

7

High-throughput

0.515

High

632671

STM1
Suppressor protein STM1

1

2

High-throughput

0.515

High

632731

HMO1
High mobility group protein 1

1

13

High-throughput

0.515

High

632757

RRS1
Regulator of ribosome biosynthesis

1

6

High-throughput

0.515

High

632763

YRA1
RNA annealing protein YRA1

1

9

High-throughput

0.515

High

632764

MAK21
Ribosome biogenesis protein MAK21

1

17

High-throughput

0.515

High

441034

KAPA
cAMP-dependent protein kinase type 1

1

11

High-throughput

0.501

High

448640

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.501

High

632614

KC11
Casein kinase I homolog 1

1

9

High-throughput

0.501

High

632620

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

8

High-throughput

0.501

High

632705

ATG1
Serine/threonine-protein kinase ATG1

1

4

High-throughput

0.501

High

632728

SKY1
Serine/threonine-protein kinase SKY1

1

20

High-throughput

0.501

High

632760

RTK1
Probable serine/threonine-protein kinase RTK1

1

6

High-throughput

0.501

High

632616

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.493

High

394228

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.489

High

427134

RLA0
Large ribosomal subunit protein uL10

1

12

High-throughput

0.489

High

632664

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

3

High-throughput

0.489

High

632704

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

3

High-throughput

0.489

High

632767

SMT3
Ubiquitin-like protein SMT3

1

3

High-throughput

0.481

High

149579

RS9A
Small ribosomal subunit protein uS4A

1

11

High-throughput

0.479

High

409930

RL25
Large ribosomal subunit protein uL23

1

10

High-throughput

0.479

High

433443

RL26A
Large ribosomal subunit protein uL24A

1

13

High-throughput

0.479

High

434816

RS3
Small ribosomal subunit protein uS3

1

8

High-throughput

0.479

High

435768

RS13
Small ribosomal subunit protein uS15

1

7

High-throughput

0.479

High

441700

RS14A
Small ribosomal subunit protein uS11A

1

11

High-throughput

0.479

High

454870

RS19A
Small ribosomal subunit protein eS19A

1

14

High-throughput

0.479

High

512009

RS4A
Small ribosomal subunit protein eS4A

1

4

High-throughput

0.479

High

512252

RS6A
Small ribosomal subunit protein eS6A

1

10

High-throughput

0.479

High

513626

RL2A
Large ribosomal subunit protein uL2A

1

11

High-throughput

0.479

High

632621

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

632622

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

632623

RS2
Small ribosomal subunit protein uS5

1

9

High-throughput

0.479

High

632631

SPT5
Transcription elongation factor SPT5

1

4

High-throughput

0.479

High

632633

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.479

High

632634

BMH1
Protein BMH1

1

8

High-throughput

0.479

High

632640

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

5

High-throughput

0.479

High

632646

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

8

High-throughput

0.479

High

632652

UTP11
U3 small nucleolar RNA-associated protein 11

1

2

High-throughput

0.479

High

632653

RS27A
Small ribosomal subunit protein eS27A

1

6

High-throughput

0.479

High

632656

EAP1
Protein EAP1

1

2

High-throughput

0.479

High

632660

LONM
Lon protease homolog, mitochondrial

1

11

High-throughput

0.479

High

632669

RRP8
25S rRNA

1

6

High-throughput

0.479

High

632681

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

2

High-throughput

0.479

High

632686

UTP25
U3 small nucleolar RNA-associated protein 25

1

3

High-throughput

0.479

High

632689

DSN1
Kinetochore-associated protein DSN1

1

5

High-throughput

0.479

High

632699

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

3

Small-scale

0.479

High

632706

NSA1
Ribosome biogenesis protein NSA1

1

4

High-throughput

0.479

High

632710

PESC
Pescadillo homolog

1

6

High-throughput

0.479

High

632713

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

17

High-throughput

0.479

High

632715

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.479

High

632716

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

13

High-throughput

0.479

High

632717

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.479

High

632720

RS15
Small ribosomal subunit protein uS19

1

7

High-throughput

0.479

High

632723

XRN2
5'-3' exoribonuclease 2

1

4

High-throughput

0.479

High

632725

ESP1
Separin

1

1

High-throughput

0.479

High

632726

TOM1
E3 ubiquitin-protein ligase TOM1

1

15

High-throughput

0.479

High

632732

UTP5
U3 small nucleolar RNA-associated protein 5

1

13

High-throughput

0.479

High

632736

BUD22
Bud site selection protein 22

1

1

High-throughput

0.479

High

632740

FCF1
rRNA-processing protein FCF1

1

5

High-throughput

0.479

High

632751

CMS1
Protein CMS1

1

1

High-throughput

0.479

High

632752

RCL1
rRNA processing protein RCL1

1

1

High-throughput

0.479

High

632754

SGO1
Shugoshin

1

5

High-throughput

0.479

High

632755

ESA1
Histone acetyltransferase ESA1

1

4

Small-scale

0.479

High

632756

RS10A
Small ribosomal subunit protein eS10A

1

10

High-throughput

0.479

High

632758

BMS1
Ribosome biogenesis protein BMS1

1

6

High-throughput

0.479

High

632766

UTP12
U3 small nucleolar RNA-associated protein 12

1

15

High-throughput

0.479

High

632773

EFG1P
rRNA-processing protein EFG1

1

1

High-throughput

0.479

High

632774

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

632639

EF2
Elongation factor 2

1

9

High-throughput

0.470

High

632678

RV167
Reduced viability upon starvation protein 167

1

6

High-throughput

0.470

High

632707

MLC1
Myosin light chain 1

1

3

High-throughput

0.470

High

632670

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

632687

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

632722

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

632745

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

632759

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

392210

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

432484

RL7A
Large ribosomal subunit protein uL30A

1

17

High-throughput

0.445

High

510183

HSP77
Import motor subunit, mitochondrial

1

8

High-throughput

0.445

High

525898

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

569902

RL3
Large ribosomal subunit protein uL3

1

9

High-throughput

0.445

High

578826

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.445

High

597031

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.445

High

626577

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

632624

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.445

High

632628

RL16A
Large ribosomal subunit protein uL13A

1

16

High-throughput

0.445

High

632638

HS104
Heat shock protein 104

1

6

High-throughput

0.445

High

632641

ZUO1
Zuotin

1

7

High-throughput

0.445

High

632643

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

632644

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

632649

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.445

High

632654

LHS1
Heat shock protein 70 homolog LHS1

1

16

High-throughput

0.445

High

632662

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

8

High-throughput

0.445

High

632667

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

632672

TCPB
T-complex protein 1 subunit beta

1

5

High-throughput

0.445

High

632673

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.445

High

632674

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.445

High

632675

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.445

High

632676

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

632682

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

632698

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.445

High

632703

RL4B
Large ribosomal subunit protein uL4B

1

11

High-throughput

0.445

High

632718

SEN1
Helicase SEN1

1

9

Small-scale

0.445

High

632721

RL6A
Large ribosomal subunit protein eL6A

1

8

High-throughput

0.445

High

632765

RL7B
Large ribosomal subunit protein uL30B

1

17

High-throughput

0.445

High

383515

RS17A
Small ribosomal subunit protein eS17A

1

7

High-throughput

0.437

High

502846

RS22A
Small ribosomal subunit protein uS8A

1

8

High-throughput

0.437

High

504035

RL31A
Large ribosomal subunit protein eL31A

1

15

High-throughput

0.437

High

512814

RS8A
Small ribosomal subunit protein eS8A

1

10

High-throughput

0.437

High

514452

RS18A
Small ribosomal subunit protein uS13A

1

6

High-throughput

0.437

High

632647

RSSA1
Small ribosomal subunit protein uS2A

1

12

High-throughput

0.437

High

632650

RS3A1
Small ribosomal subunit protein eS1A

1

9

High-throughput

0.437

High

632665

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.437

High

632677

LAA1
AP-1 accessory protein LAA1

1

7

High-throughput

0.437

High

632708

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.437

High

632729

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

632735

VMS1
tRNA endonuclease VMS1

1

3

High-throughput

0.437

High

632738

POB3
FACT complex subunit POB3

1

7

High-throughput

0.437

High

632750

VAM6
Vacuolar morphogenesis protein 6

1

5

High-throughput

0.437

High

632619

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.407

High

632684

JEM1
DnaJ-like chaperone JEM1

1

5

High-throughput

0.407

High

632688

DJP1
DnaJ-like protein 1

1

8

High-throughput

0.407

High

632690

RL10
Large ribosomal subunit protein uL16

1

12

High-throughput

0.407

High

632694

ERJ5
ER-localized J domain-containing protein 5

1

7

High-throughput

0.407

High

632701

HLJ1
Protein HLJ1

1

3

High-throughput

0.407

High

632768

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

613806

FUN14
Protein FUN14

1

0

High-throughput

0.269

Low

632730

ENT5
Epsin-5

1

0

High-throughput

0.269

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025