HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN2D (Q60773)
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Gene: Cdkn2d

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	7739548
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0097129 - cyclin D2-CDK4 complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 166
+	Mm
		1141372 CDK6_MOUSE (5-303): 4.02e-128: 369: 67.67		CDN2D_MOUSE (1-166): 4.49e-55: 172: 100.00
+	Hs
		515390 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2D_HUMAN (1-166): 1.48e-53: 168: 86.75
+	Hs
		877470 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2D_HUMAN (1-166): 1.48e-53: 168: 86.75
+	Mm
		673234 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		CDN2C_MOUSE (9-163): 7.76e-47: 151: 42.68
+	Hs
		515365 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2C_HUMAN (9-163): 6.87e-46: 149: 43.95
+	Hs
		790967 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2C_HUMAN (9-163): 6.87e-46: 149: 43.95
+	Hs
		625621 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		RAI14_HUMAN (1-100): 2.37e-23: 97.3: 23.08
+	Hs
		276137 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		PSD10_HUMAN (48-165): 2.8e-35: 124: 21.67
+	Mm
		673242 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		PSD10_MOUSE (48-165): 2.77e-35: 124: 21.67
+	Mm
		673230 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		CDN2B_MOUSE (12-126): 7.61e-26: 97.1: 52.59
+	Hs
		515364 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2B_HUMAN (12-126): 2.37e-25: 96.3: 52.59
+	Hs
		790922 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2B_HUMAN (12-126): 2.37e-25: 96.3: 52.59
+	Hs
		515363 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CDN2A_HUMAN (9-126): 2.69e-23: 91.3: 51.26
+	Hs
		790748 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		CDN2A_HUMAN (9-126): 2.69e-23: 91.3: 51.26
+	Mm
		673228 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		CDN2A_MOUSE (18-126): 3.04e-21: 86.7: 49.09
+	Hs
		960304 CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75		MIB1_HUMAN (11-114): 7.85e-16: 75.6: 20.55
+	Hs
		515476 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		ANR52_HUMAN (12-158): 1.87e-12: 65.9: 36.67